Evidence map›Paper›PMID 30042166›Full record

ArticleBioscience reports2018

LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21.

Fan Fei, Yongsheng He, Sen He, Zhongze He, Youyu Wang, Gang Wu, Mengni Li

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. CRNDE/ETS1/GPR17 Facilitates the Proliferation, Migration, and Invasion of Glioma.Computational and mathematical methods in medicine · 2021
    Article
  13. Article
  14. Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis.Frontiers in cell and developmental biology · 2021
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fan FeiDepartment of Neurosurgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China.
Yongsheng HeDepartment of Neurosurgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China.
Sen HeDepartment of Neurosurgery, Graduate School of Zunyi Medical University, Zunyi 563003, Guizhou, China.
Zhongze HeDepartment of Neurosurgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China.
Youyu WangDepartment of Thoracic Surgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China.
Gang WuDepartment of Hepatobiliary surgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China.
Mengni LiDepartment of Pediatrics, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China mengnl2i@163.com.
University of Electronic Science and Technology of China · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level of SNHG3 in glioma tissues and cells and evaluated the effect of SNHG3 expression on the prognosis of glioma patients. The functional assays were applied to define the effects of SNHG3 on the biological behaviors in glioma including cell proliferation, cell cycle, and apoptosis. It was revealed that SNHG3 was much more enriched in glioma tissues and cell lines than in normal ones. Furthermore, gain- or loss-of-function experiments indicated that the up-regulation of SNHG3 promoted cell proliferation, accelerate cell cycle progress, and repressed cell apoptosis. The mechanistic assays disclosed that SNHG3 facilitated the malignant progression of glioma through epigenetically repressing KLF2 and p21 via recruiting enhancer of zeste homolog 2 to the promoter of KLF2 and p21. Generally, it was exposed that SNHG3 might function as an oncogene in glioma and could be explored as a potential prognostic biomarker and therapeutic target for glioma.

Indexed as

ApoptosisBrain NeoplasmsCell Cycle CheckpointsCell Line, TumorCyclin-Dependent Kinase Inhibitor p21Enhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticGliomaHumansKruppel-Like Transcription FactorsMaleMiddle AgedPrognosisPromoter Regions, GeneticCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Enhancer of Zeste Homolog 2 ProteinEZH2 protein, humanKLF2 protein, humanKruppel-Like Transcription Factorslong non-coding RNA SNHG5, humanRNA, Long NoncodinggliomaKLF2p21SNHG3

Identifiers

PMID30042166
PMCPMC6127675
OpenAlexW2884154474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.