SynthesisBlood2018
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.
Erratum issuedOpen access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Accelerated transcriptomic age and susceptibility to traffic-related air pollution among cardiac catheterization patients.The Science of the total environment · 2025Article
- The Association Study of Targeted DNA Methylation and Thrombophilia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Biological Aging and Uterine Fibrosis in Cattle: Reproductive Trade-Offs from Enhanced Productivity.Cells · 2025Review
- Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study.Clinical epigenetics · 2025Article
- Review
- GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.Cell death & disease · 2023Article
- The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes.Clinical epigenetics · 2022Article
- Article
- DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.Clinical epigenetics · 2021Article
- The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.Circulation research · 2021Review
- Article
- Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.Aging · 2020Article
- Article
- Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.PloS one · 2019Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
54 authors at 20 institutions in 8 countries.
Cavin K Ward-CavinessInstitute of Epidemiology II, Helmholtz Center of Munich, Neuherberg, Germany.ORCID 0000-0002-6322-4349
Jennifer E HuffmanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Karl EverettDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Marine GermainSorbonne Universités, UPMC University Paris 06, INSERM UMR_S 1166, Paris, France.
Jenny van DongenBiological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-2063-8741
W David HillCentre for Cognitive Ageing and Cognitive Epidemiology and.
Min A JhunDepartment of Epidemiology, University of Michigan, Ann Arbor, MI.
Jennifer A BrodyCardiovascular Health Research Unit, University of Washington, Seattle, WA.
Mohsen GhanbariDepartment of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-9476-7143
Lei DuCardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Nicholas S RoetkerDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Melanie WaldenbergerInstitute of Epidemiology II, Helmholtz Center of Munich, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology and.
Petra WolfInstitue of Human Genetics, Helmholtz Center of Munich, Neuherberg, Germany.
Holger ProkischInstitue of Human Genetics, Helmholtz Center of Munich, Neuherberg, Germany.
Wolfgang KoenigDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Christopher J O'DonnellThe Framingham Heart Study, Framingham, MA.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Vinh TruongDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Philip S WellsDepartment of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-8657-8326
David-Alexandre TrégouëtSorbonne Universités, UPMC University Paris 06, INSERM UMR_S 1166, Paris, France.ORCID 0000-0001-9084-7800
Weihong TangDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.ORCID 0000-0001-6381-4296
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Kerri L WigginsCardiovascular Health Research Unit, University of Washington, Seattle, WA.ORCID 0000-0003-2749-1279
Barbara McKnightCardiovascular Health Research Unit, University of Washington, Seattle, WA.
Xiuqing GuoDepartment of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrence, CA.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, WA.
Nona SotoodeniaCardiovascular Health Research Unit, University of Washington, Seattle, WA.
Dorret I BoomsmaBiological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
Gonneke WillemsenBiological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Lannie LigthartBiological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology and.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI.
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-4731-8158
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI.
Joyce B J Van MeursDepartment of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Per ErikssonCardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Anders Franco-CerecedaCardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
James S PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Andrew D JohnsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
France GagnonDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Pierre-Emmanuel MorangeLaboratory of Hematology, La Timone Hospital, Marseille, France.
Eco J C de GeusBiological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology and.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Hanna M BjörckCardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Nicholas L SmithCardiovascular Health Research Unit, University of Washington, Seattle, WA.
Annette PetersInstitute of Epidemiology II, Helmholtz Center of Munich, Neuherberg, Germany.
University of Michigan · USVrije Universiteit Amsterdam · NLErasmus MC · NLHelmholtz Zentrum München · DENational Institutes of Health · USUniversity of Washington · USInserm · FRKarolinska University Hospital · SEUniversity of Minnesota · USUniversity of Toronto · CAKaiser Permanente Washington Health Research Institute · USThe University of Texas Health Science Center at Houston · USUniversity of Edinburgh · GBAlzheimer Scotland · GBBaylor College of Medicine · USEnvironmental Protection Agency · USKarolinska Institutet · SEMashhad University of Medical Sciences · IRMRC Epidemiology Unit · GBUCLA Medical Center · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MThe Family Blood Pressure Program (GENOA Network)U01HL054481 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A · 2000 to 2007
$6.7MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MProspective meta-analyses of drug-gene interactions: CHARGE GWAS consortiumR01HL103612 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2011 to 2014
$5.4MGenome-wide study of sudden cardiac arrest in the communityR01HL092111 · NHLBI · UNIVERSITY OF WASHINGTON · PI SOTOODEHNIA, NONA · 2009 to 2011
$5.3MBiotechnology and Biological Sciences Research Council BB/F019394/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS K08 HL116640NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01 HL134894NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG055406NIDDK NIH HHS P30 DK063491
Abstract
Many hemostatic factors are associated with age and age-related diseases; however, much remains unknown about the biological mechanisms linking aging and hemostatic factors. DNA methylation is a novel means by which to assess epigenetic aging, which is a measure of age and the aging processes as determined by altered epigenetic states. We used a meta-analysis approach to examine the association between measures of epigenetic aging and hemostatic factors, as well as a clotting time measure. For fibrinogen, we performed European and African ancestry-specific meta-analyses which were then combined via a random effects meta-analysis. For all other measures we could not estimate ancestry-specific effects and used a single fixed effects meta-analysis. We found that 1-year higher extrinsic epigenetic age as compared with chronological age was associated with higher fibrinogen (0.004 g/L/y; 95% confidence interval, 0.001-0.007;
Indexed as
DNA MethylationAgingEpigenesis, GeneticHemostasisHumans
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