Evidence map›Paper›PMID 30041981›Full record

ArticleInternational journal of cardiology2018

Inverse association of MRI-derived native myocardial T1 and perfusion reserve index in women with evidence of ischemia and no obstructive CAD: A pilot study.

Jaime L Shaw, Michael D Nelson, Janet Wei, Manish Motwani, Sofy Landes, Puja K Mehta, Louise E J Thomson, Daniel S Berman, Debiao Li, C Noel Bairey Merz and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06641843 (Magnetic Resonance Myocardial Stress Perfusion), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06641843 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Magnetic Resonance Myocardial Stress Perfusion: to Improve the Myocardial Evaluation in Pediatric Patients with Cardiovascular Disease

TypeobservationalSponsorWest China Second University HospitalRan2024 to 2034Enrolled240ConditionsKawasaki Disease, Cardiovascular Disease, Anomalous Origin of Coronary Artery
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Quantitative imaging in medicine and surgery · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Can EAT be an INOCA goalkeeper.Frontiers in endocrinology · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Cardiovascular disease in women: insights from magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jaime L ShawBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Bioengineering, University of California Los Angeles, CA, United States.
Michael D NelsonBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
Janet WeiBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
Manish MotwaniDepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Sofy LandesWomen's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
Puja K MehtaWomen's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
Louise E J ThomsonWomen's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States; Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Daniel S BermanBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States; David Geffen School of Medicine, University of California Los Angeles, CA, United States.
Debiao LiBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Bioengineering, University of California Los Angeles, CA, United States; David Geffen School of Medicine, University of California Los Angeles, CA, United States.
C Noel Bairey MerzWomen's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, United States; David Geffen School of Medicine, University of California Los Angeles, CA, United States.
Behzad SharifBiomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Bioengineering, University of California Los Angeles, CA, United States; David Geffen School of Medicine, University of California Los Angeles, CA, United States. Electronic address: behzad.sharif@cshs.org.
Cedars-Sinai Medical Center · USCedars-Sinai Smidt Heart Institute · USUniversity of California, Los Angeles · US

Funding

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Accurate Perfusion MRI for Improved Diagnosis of Microvascular Coronary DiseaseR00HL124323 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHARIF, BEHZAD · 2017 to 2019
$747k
NHLBI NIH HHS R00 HL124323NHLBI NIH HHS R01 HL090957
6 · The paper itself

Abstract

backgroundIt has recently been shown that magnetic resonance (MR) "native T1" mapping is capable of characterizing abnormal microcirculation in patients with obstructive coronary artery disease (CAD). In studies involving women with signs and symptoms of ischemia and no obstructive CAD (INOCA), however, the potential role of native T1 as an imaging marker and its association with indices of diastolic function or vasodilator-induced myocardial ischemia have not been explored. We investigated whether native T1 in INOCA is associated with reduced myocardial perfusion reserve index (MPRI) or with diastolic dysfunction.

methodsTwenty-two female patients with INOCA and twelve female reference controls with matching age and body-mass index were studied. The patients had evidence of vasodilator-induced ischemia without obstructive CAD or any prior infarction. All 34 subjects underwent stress/rest MR including native T1 mapping (MOLLI 5(3)3) at 1.5-Tesla.

resultsCompared with controls, patients had similar morphology/function. As expected, MPRI was significantly reduced in patients compared to controls (1.78 ± 0.39 vs. 2.49 ± 0.41, p < 0.0001). Native T1 was significantly elevated in patients (1040.1 ± 29.3 ms vs. 1003.8 ± 18.5 ms, p < 0.001) and the increased T1 showed a significant inverse correlation with MPRI (r = -0.481, p = 0.004), but was not correlated with reduced diastolic strain rate.

conclusionsSymptomatic women with INOCA have elevated native T1 compared to matched reference controls and there is a significant association between elevated native T1 and impaired MPRI, considered a surrogate measure of ischemia severity in this cohort. Future studies in a larger cohort are needed to elucidate the mechanism underlying this inverse relationship.

Indexed as

AgedCoronary Artery DiseaseFemaleHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMiddle AgedMyocardial IschemiaMyocardial Perfusion ImagingPilot ProjectsCoronary microcirculationCoronary microvascular dysfunctionMicrovascular anginaMyocardial perfusionMyocardial T1Nonobstructive coronary artery disease

Identifiers

PMID30041981
PMCPMC6139276
OpenAlexW2808936706

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.