ArticleBMC research notes2018
The agr quorum sensing system in Staphylococcus aureus cells mediates death of sub-population.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- CRISPR-driven strategies to disrupt methicillin-resistantFrontiers in cellular and infection microbiology · 2026Review
- Anti-Biofilm Properties of Cell-Free Supernatant fromMicroorganisms · 2025Article
- Molecular structural arrangement in quorum sensing and bacterial metabolic production.World journal of microbiology & biotechnology · 2025Review
- Unravelling the physicochemical and antimicrobial mechanisms of human serum albumin/tannic acid coatings for medical-grade polycaprolactone scaffolds.Bioactive materials · 2024Article
- Temporal modelling of the biofilm lifecycle (TMBL) establishes kinetic analysis of plate-based bacterial biofilm dynamics.Journal of microbiological methods · 2023Article
- Quorum sensing interference by phenolic compounds - A matter of bacterial misunderstanding.Heliyon · 2023Review
- Quorum Sensing as a Trigger That Improves Characteristics of Microbial Biocatalysts.Microorganisms · 2023Review
- Biocomputational Identification of sRNAs inIndian journal of microbiology · 2023Article
- Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-Antibiotics (Basel, Switzerland) · 2023Article
- TargetingFrontiers in oncology · 2023Article
- Terpenes Combinations Inhibit Biofilm Formation inMicroorganisms · 2022Article
- The Fusaric Acid Derivative qy17 InhibitsFrontiers in microbiology · 2022Article
- Effect of Cobalt-Chromium-Molybdenum Implant Surface Modifications on Biofilm Development ofFrontiers in cellular and infection microbiology · 2022Article
- Therapeutic implications ofVirulence · 2021Article
- Gene Regulation of Biofilm-Associated Functional Amyloids.Pathogens (Basel, Switzerland) · 2021Review
- Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by UpregulatingAntimicrobial agents and chemotherapy · 2020Article
- Oxidative stress drives the selection of quorum sensing mutants in theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Identification of Genes Regulating Cell Death inFrontiers in microbiology · 2019Article
- Recent advances in the use of resveratrol againstMedicine internationalReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveIn the human pathogen, Staphylococcus aureus, the agr quorum sensing system controls expression of a multitude of virulence factors and yet, agr negative cells frequently arise both in the laboratory and in some infections. The aim of this study was to examine the possible reasons behind this phenomenon.
resultsWe examined viability of wild type and agr mutant cell cultures using a live-dead stain and observed that in stationary phase, 3% of the wild type population became non-viable whereas for agr mutant cells non-viable cells were barely detectable. The effect appears to be mediated by RNAIII, the effector molecule of agr, as ectopic overexpression of RNAIII resulted in 60% of the population becoming non-viable. This effect was not due to toxicity from delta toxin that is encoded by the hld gene located within RNAIII as hld overexpression did not cause cell death. Importantly, lysed S. aureus cells promoted bacterial growth. Our data suggest that RNAIII mediated cell death of agr positive but not agr negative cells provides a selective advantage to the agr negative cell population and may contribute to the common appearance of agr negative cells in S. aureus populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.