Evidence map›Paper›PMID 30041606›Full record

ArticleBMC cardiovascular disorders2018

Non-adherence to antihypertensive pharmacotherapy in Buea, Cameroon: a cross-sectional community-based study.

Nkengla Menka Adidja, Valirie Ndip Agbor, Jeannine A Aminde, Calypse A Ngwasiri, Kathleen Blackett Ngu, Leopold Ndemnge Aminde

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nkengla Menka AdidjaFaculty of Health Sciences, University of Buea, Buea, Cameroon.
Valirie Ndip AgborIbal Sub-divisional Hospital, Oku, Cameroon.
Jeannine A AmindeFaculty of Health Sciences, University of Buea, Buea, Cameroon.
Calypse A NgwasiriBamendjou District Hospital, Bamendjou, Cameroon.
Kathleen Blackett NguFaculty of Medicine & Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Leopold Ndemnge AmindeFaculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Australia. amindeln@gmail.com.ORCID 0000-0003-2787-7518
Université de Yaoundé I · CMUniversity of Buea · CMThe University of Queensland · AUUniversity of Douala · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is a challenging public health problem with a huge burden in the developing countries. Non-adherence to antihypertensive treatment is a big obstacle in blood pressure (BP) control and favours disease progression to complications. Our objectives were to determine the rate of non-adherence to antihypertensive pharmacotherapy, investigate factors associated with non-adherence, and to assess the association between non-adherence and BP control in the Buea Health District (BHD), Cameroon.

methodsA community-based cross-sectional study using stratified cluster sampling was conducted in the BHD from November 2013 - March 2014. Eligible consenting adult participants had their BP measured and classified using the Joint National Committee VII criteria. The Morisky medication adherence scale was used to assess adherence to BP lowering medication. Multivariable logistic regression models were used to predict non-adherence.

resultsOne hundred and eighty-three participants were recruited with mean age of 55.9 years. Overall, 67.7% (95% CI: 59.8-73.6%) of participants were non-adherent to their medications. After adjusting for age, sex and other covariates, forgetfulness (aOR = 7.9, 95%CI: 3.0-20.8), multiple daily doses (aOR = 2.5, 95%CI: 1.2-5.6), financial constraints (aOR = 2.8, 95%CI: 1.1-6.9) and adverse drug effects (aOR = 7.6, 95%CI: 1.7-33.0) independently predicted non-adherence to anti-hypertensive medication. BP was controlled in only 21.3% of participants and was better in those who were adherent to medication (47.5% versus 8.2%, p <  0.01).

conclusionAt least two of every three hypertensive patients in the Buea Health District are non-adherent to treatment. Forgetfulness, multiple daily doses of medication, financial constraints and medication adverse effects are the major predictors of non-adherence in hypertensive patients. These factors should be targeted to improve adherence and BP control, which will contribute to stem hypertension-related morbidity and mortality.

Indexed as

Medication AdherenceAdultAgedAntihypertensive AgentsBlood PressureCameroonCross-Sectional StudiesDrug Administration ScheduleDrug CostsFemaleHealth Knowledge, Attitudes, PracticeHumansHypertensionMaleMiddle AgedPrevalenceAntihypertensive AgentsCameroonHypertensionMedication adherenceMorisky scaleNon-adherence

Identifiers

PMID30041606
PMCPMC6056997
OpenAlexW2883458402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.