ReviewJournal of neurogastroenterology and motility2018
Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.
Review in Journal of neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Resting-state functional MRI activity and connectivity in inflammatory bowel disease: a systematic review.Neuroradiology · 2025Pooled it
- Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies.BMC gastroenterology · 2024Pooled it
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies.Frontiers in neuroscience · 2023Pooled it
- Guideline
- Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review.World journal of gastroenterology · 2020Pooled it
- The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia.Brain imaging and behavior · 2021Trial
- Altered neurovascular coupling and associated neurotransmitter profiles in inflammatory bowel disease with distinct depressive symptoms.Journal of neuroinflammation · 2026Article
- The Gut-Brain Axis-From Science to Clinical Practice.Gastro hep advances · 2026Review
- Painful Disorders of Gut-Brain Interaction Are More Associated With Worse Health-Related Quality of Life and Psychological Disorders Than Non-Painful Disorders in Latin American Countries.Neurogastroenterology and motility · 2025Article
- The threat of an embodied virtual belly affects gastric feelings depending on somatic, interoceptive and alexithymic characteristics of healthy women.Scientific reports · 2025Article
- The Small Intestinal Microbiota and the Gut-Brain Axis in Parkinson's Disease: A Narrative Review.Biomedicines · 2025Review
- Research progress on the mechanisms of comorbidity between functional gastrointestinal disorders and mental disorders: A review.Medicine · 2025Review
- Resting functional magnetic resonance images of the brain in functional gastrointestinal diseases: a concise review of the literature.Gastroenterology and hepatology from bed to bench · 2025Review
- Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity and Anxiety via ACC-AIC Circuit Modulation in IBS Rats.Neuropsychiatric disease and treatment · 2025Article
- A multidisciplinary approach to the management of disorders of gut-brain interaction: psychopharmacology, psychotherapy, and diet.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Neural circuits regulating visceral pain.Communications biology · 2024Review
- Aberrant intrinsic brain activities in functional gastrointestinal disorders revealed by seed-based d mapping with permutation of subject images.Frontiers in neuroscience · 2024Review
- Abnormalities of white matter network properties in middle-aged and elderly patients with functional constipation.Frontiers in neurology · 2024Article
- Clinical-functional brain connectivity signature predicts longitudinal symptom improvement after acupuncture treatment in patients with functional dyspepsia.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline of brain activity at rest associated with self-awareness and memory) in FGIDs. Structural imaging with brain morphometry and diffusion imaging demonstrated altered gray- and white-matter structures in areas that also showed changes in functional imaging studies, although this requires replication. Molecular imaging by magnetic resonance spectroscopy and positron emission tomography in FGIDs remains relatively sparse. Progress using analytical methods such as machine learning algorithms may shift neuroimaging studies from brain mapping to predicting clinical outcomes. Because several factors contribute to the pathophysiology of FGIDs and because its population is quite heterogeneous, a new model is needed in future studies to assess the importance of the factors and brain functions that are responsible for an optimal homeostatic state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.