ReviewNeuroImage2019
Exploring early human brain development with structural and physiological neuroimaging.
Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fetal brain MRI atlases and datasets: A review.NeuroImage · 2024Pooled it
- Latent representations of early brain development: A multivariate normative model of brain structure and behaviour.Developmental cognitive neuroscience · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Measures of Brain Metabolism and Diffusion in Neonates of Mothers with Diabetes.AJNR. American journal of neuroradiology · 2026Article
- Neonatal brain age estimation from T2-weighted magnetic resonance images using shallow regression analysis.Scientific reports · 2026Article
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025Review
- Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study.Nutrition journal · 2025Article
- Bioengineering innovations for neural organoids with enhanced fidelity and function.Cell stem cell · 2025Review
- A Cost-Effective Method for the Spectral Calibration of Photoplethysmography Pulses: The Optimal Wavelengths for Heart Rate Monitoring.Sensors (Basel, Switzerland) · 2025Article
- Understanding the development of a functional brain circuit: reward processing as an illustration.Translational psychiatry · 2025Review
- Monte Carlo Guidance for Better Imaging of Boreal Lakes in the Wavelength Region of 400-800 nm.Sensors (Basel, Switzerland) · 2025Article
- Measuring the effects of motion corruption in fetal fMRI.Human brain mapping · 2025Article
- DHARANI: A 3D Developing Human-Brain Atlas Resource to Advance Neuroscience Internationally Integrated Multimodal Imaging and High-Resolution Histology of the Second Trimester.The Journal of comparative neurology · 2025Article
- Article
- Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.Current topics in behavioral neurosciences · 2025Review
- Gestational Duration and Postnatal Age-Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG).Human brain mapping · 2025Article
- A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.Scientific reports · 2024Article
- Individualized post-operative prediction of cochlear implantation outcomes in children with prelingual deafness using functional near-infrared spectroscopy.Laryngoscope investigative otolaryngology · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Early brain development, from the embryonic period to infancy, is characterized by rapid structural and functional changes. These changes can be studied using structural and physiological neuroimaging methods. In order to optimally acquire and accurately interpret this data, concepts from adult neuroimaging cannot be directly transferred. Instead, one must have a basic understanding of fetal and neonatal structural and physiological brain development, and the important modulators of this process. Here, we first review the major developmental milestones of transient cerebral structures and structural connectivity (axonal connectivity) followed by a summary of the contributions from ex vivo and in vivo MRI. Next, we discuss the basic biology of neuronal circuitry development (synaptic connectivity, i.e. ensemble of direct chemical and electrical connections between neurons), physiology of neurovascular coupling, baseline metabolic needs of the fetus and the infant, and functional connectivity (defined as statistical dependence of low-frequency spontaneous fluctuations seen with functional magnetic resonance imaging (fMRI)). The complementary roles of magnetic resonance imaging (MRI), electroencephalography (EEG), magnetoencephalography (MEG), and near-infrared spectroscopy (NIRS) are discussed. We include a section on modulators of brain development where we focus on the placenta and emerging placental MRI approaches. In each section we discuss key technical limitations of the imaging modalities and some of the limitations arising due to the biology of the system. Although neuroimaging approaches have contributed significantly to our understanding of early brain development, there is much yet to be done and a dire need for technical innovations and scientific discoveries to realize the future potential of early fetal and infant interventions to avert long term disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.