ReviewThe Journal of allergy and clinical immunology2018
Transgenerational and intergenerational epigenetic inheritance in allergic diseases.
Review in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- The enteric DNA virome differs in infants at risk for atopic disease.Gut microbes · 2026Article
- Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction.Nature metabolism · 2026Article
- Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non-mammalian Models.Environmental toxicology · 2026Review
- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence.Current issues in molecular biology · 2025Review
- Observational methods for human studies of transgenerational effects.Epigenetics · 2024Article
- Sex Disparities in Asthma Related to Parental and Grandmaternal Smoking Habits-A Population-Based Register Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024Article
- Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review.Journal of personalized medicine · 2024Review
- Environmental and Genetic Traffic in the Journey from Sperm to Offspring.Biomolecules · 2023Review
- A review of plant epigenetics through the lens of almond.The plant genome · 2023Review
- Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023Review
- Transgenerational epigenetic inheritance: Perspectives and challenges.The Journal of allergy and clinical immunology · 2023Article
- Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe.Frontiers in allergy · 2023Article
- A synthetic glycodendropeptide induces methylation changes on regulatory T cells linked to tolerant responses in anaphylactic-mice.Frontiers in immunology · 2023Article
- The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- A Review on Epigenetic Inheritance of Experiences in Humans.Biochemical genetics · 2022Review
- Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort.BMJ open · 2022Article
- Nano-titanium dioxide inhalation exposure during gestation drives redox dysregulation and vascular dysfunction across generations.Particle and fibre toxicology · 2022Article
- Early-Life Adversity Due to Bereavement and Inflammatory Diseases in the Next Generation: A Population Study in Transgenerational Stress Exposure.American journal of epidemiology · 2022Article
Corrections and comments
- Commented on byReply.2019
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Authors and funding
6 authors.
Funding
Abstract
It has become clear that early life (including in utero exposures) is a key window of vulnerability during which environmental exposures can alter developmental trajectories and initiate allergic disease development. However, recent evidence suggests that there might be additional windows of vulnerability to environmental exposures in the parental generation before conception or even in previous generations. There is evidence suggesting that information of prior exposures can be transferred across generations, and experimental animal models suggest that such transmission can be conveyed through epigenetic mechanisms. Although the molecular mechanisms of intergenerational and transgenerationational epigenetic transmission have yet to be determined, the realization that environment before conception can alter the risks of allergic diseases has profound implications for the development of public health interventions to prevent disease. Future research in both experimental models and in multigenerational human cohorts is needed to better understand the role of intergenerational and transgenerational effects in patients with asthma and allergic disease. This will provide the knowledge basis for a new approach to efficient intervention strategies aimed at reducing the major public health challenge of these conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.