Evidence map›Paper›PMID 30040719›Full record

Trial reportJournal of Alzheimer's disease : JAD2018

Change in Fitness and the Relation to Change in Cognition and Neuropsychiatric Symptoms After Aerobic Exercise in Patients with Mild Alzheimer's Disease.

Nanna A Sobol, Christian Have Dall, Peter Høgh, Kristine Hoffmann, Kristian Steen Frederiksen, Asmus Vogel, Volkert Siersma, Gunhild Waldemar, Steen G Hasselbalch, Nina Beyer

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  5. Functional Therapeutic Strategies Used in Different Stages of Alzheimer's Disease-A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  11. Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  12. Review
  13. Advancements in Therapy for Alzheimer's Disease Based on the Cerebral Lymphatic System.Degenerative neurological and neuromuscular disease · 2026
    Article
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  20. A Literature Review of High-Tech Physiotherapy Interventions in the Elderly with Neurological Disorders.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nanna A SobolDepartment of Physical and Occupational Therapy and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Christian Have DallDepartment of Physical and Occupational Therapy and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Peter HøghZealand University Hospital, Regional Dementia Research Centre, Department of Neurology, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Kristine HoffmannDanish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark.
Kristian Steen FrederiksenDanish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark.
Asmus VogelDanish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark.
Volkert SiersmaThe Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Gunhild WaldemarDanish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark.
Steen G HasselbalchDanish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark.
Nina BeyerDepartment of Physical and Occupational Therapy and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Copenhagen University Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysical activity has the potential to improve physical function in patients with Alzheimer's disease (AD) and may contribute to modify disease processes and cognitive function.

objectiveThe aim of this study was to investigate 1) the effect of moderate-high-intensity aerobic exercise on cardiorespiratory fitness, i.e., peak oxygen uptake (VO2peak) determined by direct breath-by-breath cardiopulmonary exercise test, and 2) the association between changes in VO2peak and changes in cognition and neuropsychiatric symptoms in patients with mild AD.

methodsThe study is based on secondary outcome analyses from the large single-blinded multi-center study ADEX (Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise). A preselected sub-group of 55 participants (age 52-83 years), 29 from the intervention group (IG) and 26 from the control group (CG), was included. IG performed 16 weeks of supervised moderate-to-high intensity aerobic exercise. Assessments of VO2peak, mental speed and attention (Symbol Digit Modalities Test, SDMT), and neuropsychiatric symptoms (Neuropsychiatric Inventory, NPI) were performed at baseline and at 16 weeks.

resultVO2peak increased 13% in the IG and a between-group difference in mean change (3.92 ml/kg/min, 95% CI 6.34-1.51, p = 0.003) was present in favor of the IG. Combined data from IG and CG showed positive associations between changes in VO2peak and changes in NPI (Rho = - 0.41, p = 0.042) and changes in SDMT (Rho = 0.36, p = 0.010), respectively.

conclusionAerobic exercise improves VO2peak in community-dwelling patients with mild AD. Furthermore, changes in VO2peak appear to be associated to changes in cognition and neuropsychiatric symptoms.

Indexed as

ExerciseAgedAged, 80 and overAlzheimer DiseaseCognition DisordersDenmarkExercise TherapyFemaleHumansMaleMiddle AgedNeuropsychological TestsOxygen ConsumptionPsychiatric Status Rating ScalesRetrospective StudiesSingle-Blind Methodaerobic exerciseAlzheimer’s diseasecardiorespiratory fitnesscognitive functionneuropsychiatric symptoms

Identifiers

PMID30040719
PMCPMC6087450
OpenAlexW2884342587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.