Evidence map›Paper›PMID 30040711›Full record

ArticleJournal of Alzheimer's disease : JAD2018

FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy1.

Stephen T Chen, Prabha Siddarth, David A Merrill, Jacqueline Martinez, Natacha D Emerson, Jie Liu, Koon-Pong Wong, Nagichettiar Satyamurthy, Christopher C Giza, Sung-Cheng Huang and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02003183 (FDDNP-PET Imaging in Persons at Risk for Chronic Traumatic Encephalopathy), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02003183 completednot on this map

FDDNP-PET Imaging in Persons at Risk for Chronic Traumatic Encephalopathy

TypeobservationalSponsorUniversity of California, Los AngelesRan2013 to 2018Enrolled24ConditionsCTE, TBI (Traumatic Brain Injury)Arms[F-18]FDDNP
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. A brief history of Aβ imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Review
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  15. Article
  16. Review
  17. Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  18. Development and evaluation of [Synapse (New York, N.Y.) · 2021
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Stephen T ChenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Prabha SiddarthDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
David A MerrillDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Jacqueline MartinezDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Natacha D EmersonDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Jie LiuDepartment of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Koon-Pong WongDepartment of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Nagichettiar SatyamurthyDepartment of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Christopher C GizaDepartment of Neurosurgery at the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sung-Cheng HuangDepartment of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Robert P FitzsimmonsFitzsimmons Law Offices, Wheeling, WV, USA.
Julian BailesDepartment of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Bennet OmaluDepartment of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Jorge R BarrioDepartment of Medical and Molecular Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Gary W SmallDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USNeurobehavioral Systems · USUniversity of California Davis Medical Center · USUniversity of Chicago · USWestCare Foundation · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9M
VISUALIZING BRAIN A-BETA, TAU /SEROTONIN RECEPTOR DENSITP01AG025831 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 2005 to 2010
$7.0M
FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER'SR01AG013308 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 1995 to 2011
$4.5M
FUNCTIONAL BRAIN IMAGING AND MENTAL DISORDERS IN AGINGR01MH052453 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 1995 to 1999
–
UCLA ALZHEIMERS DISEASE CENTERP30AG010123 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CUMMINGS, JEFFREY L. · 1991 to 1998
–
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR000865NIA NIH HHS P01 AG025831NIA NIH HHS P30 AG010123NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG013308NIMH NIH HHS R01 MH052453
6 · The paper itself

Abstract

backgroundOur group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls.

objectiveTo compare these findings with those from military personnel with histories of mild traumatic brain injury(mTBI).

methodsFDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups.

resultsFDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p < 0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p = 0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p = 0.0008) and pons (p = 0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p = 0.02).

conclusionThis first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.

Indexed as

Positron-Emission TomographyAgedAlzheimer DiseaseAthletic InjuriesBrainChronic Traumatic EncephalopathyCognition DisordersHumansMagnetic Resonance ImagingMaleMiddle AgedMilitary PersonnelNitrilesProtein BindingStatistics, Nonparametrictau Proteins2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrileNitrilestau ProteinsAlzheimer’s diseasebrain tau and amyloidchronic traumatic encephalopathyFDDNP-PETmild traumatic brain injurymilitary personnelretired professional football players

Identifiers

PMID30040711
PMCPMC6728605
OpenAlexW2884137024

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.