ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2018
Integrated Histotripsy and Bubble Coalescence Transducer for Rapid Tissue Ablation.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma.Scientific reports · 2026Article
- Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Review
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.Physics in medicine and biology · 2021Article
- Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.Physics in medicine and biology · 2019Article
- Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.Physics in medicine and biology · 2019Article
- Integrated Histotripsy and Bubble Coalescence Transducer for Thrombolysis.Ultrasound in medicine & biology · 2018Article
- Coalescence of residual histotripsy cavitation nuclei using low-gain regions of the therapy beam during electronic focal steering.Physics in medicine and biology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Residual bubbles produced after collapse of a cavitation cloud provide cavitation nuclei for subsequent cavitation events, causing cavitation to occur repeatedly at the same discrete set of sites. This effect, referred to as cavitation memory, limits the efficiency of histotripsy soft tissue fractionation. Besides passively mitigating cavitation memory by using a low pulse repetition frequency (~1 Hz), an active strategy was developed by our group. In this strategy, low-amplitude ultrasound sequences were used to stimulate coalescence of residual bubbles. The goal of this work is to remove cavitation memory and achieve rapid, homogeneous lesion formation using a single phased array transducer. A 1-MHz integrated histotripsy and bubble coalescing (BC) transducer system with a specialized electronic driving system was built in house. High-amplitude ( MPa) histotripsy pulses and subsequent low-amplitude (~1-2 MPa) BC sequences were applied to a red blood cell tissue-mimicking phantom at a single focal site. Significant reduction of the cavitation memory effect and increase in the fractionation rate were observed by introducing BC sequence. Effects of BC pulsing parameters were further studied. The optimal BC parameters were then utilized to homogenize a mm
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Registered trials
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