ArticleJournal of natural products2018
A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera.
Saroopa P Samaradivakara, Radhika Samarasekera, Shiroma M Handunnetti, O V D S Jagathpriya Weerasena, Ayad A Al-Hamashi, James T Slama, William R Taylor, Qasim Alhadidi, Zahoor A Shah, Lalith Perera and 1 more
Abstract read
In one paragraphArticle in Journal of natural products, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Saroopa P SamaradivakaraInstitute of Biochemistry, Molecular Biology and Biotechnology , University of Colombo , 90, Cumaratunga Munidasa Mawatha , Colombo 03 , Sri Lanka.ORCID 0000-0002-8637-8738 Radhika SamarasekeraIndustrial Technology Institute , 363, Bauddhaloka Mawatha , Colombo 07 , Sri Lanka.
Shiroma M HandunnettiInstitute of Biochemistry, Molecular Biology and Biotechnology , University of Colombo , 90, Cumaratunga Munidasa Mawatha , Colombo 03 , Sri Lanka.
O V D S Jagathpriya WeerasenaInstitute of Biochemistry, Molecular Biology and Biotechnology , University of Colombo , 90, Cumaratunga Munidasa Mawatha , Colombo 03 , Sri Lanka.
Ayad A Al-Hamashi
James T Slama
William R Taylor
Qasim Alhadidi
Zahoor A Shah
Lalith PereraGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences , National Institutes of Health, Department of Health and Human Services , Research Triangle Park , Durham , North Carolina 27709-2233 , United States.ORCID 0000-0003-0823-1631 Funding
Macromolecular ModelingZICES043010 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COPELAND, WILLIAM · 2012 to 2025
$5.7MMACROMOLECULAR MODELING AND CARCINOGENESISZ01ES043010 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DARDEN, THOMAS A · 1986 to 2008
$1.2MNovel Small Molecule Ferroptotic Compounds to Target Mesenchymal Breast Cancer and Breast Cancer Stem CellsR15CA213185 · NCI · UNIVERSITY OF TOLEDO · PI TILLEKERATNE, VIRANGA · 2018 to 2018
$449kChemobiologic Approach to NAADP SignalingR15GM100444 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SLAMA, JAMES T · 2012 to 2012
$351kRegulation of Sororin by Cdk1-mediated Phosphorylation.R15GM100440 · NIGMS · UNIVERSITY OF TOLEDO · PI TAYLOR, WILLIAM R. · 2012 to 2012
$291kIntramural NIH HHS Z01 ES043010NCI NIH HHS R15 CA213185NIGMS NIH HHS R15 GM100440NIGMS NIH HHS R15 GM100444
6 · The paper itselfAbstract
A new resveratrol trimer, vateriferol (1), having four cis-oriented methine protons and constituting four contiguous stereocenters, was isolated from the bark extract of Vateria copallifera by bioassay-guided fractionation using a combination of normal, reversed phase, and size exclusion column chromatography. The structure was established based on its spectroscopic data. Vateriferol (1) was evaluated in vitro for its antioxidant capacity, enzyme inhibitory activity, growth inhibitory activity on a number of cancer cell lines, neuroprotective activity, and anti-inflammatory activity. Vateriferol (1) exhibited AChE inhibitory activity (IC
Indexed as
AnimalsAntineoplastic Agents, PhytogenicAntioxidantsDipterocarpaceaeDrug Screening Assays, AntitumorEnzyme InhibitorsMolecular StructureNeuroprotective AgentsPC12 CellsPlant BarkRatsResveratrolSri LankaAntineoplastic Agents, PhytogenicAntioxidantsEnzyme InhibitorsNeuroprotective AgentsResveratrol
Identifiers
PMID30040425
PMCPMC7015271
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