ArticleBiochemistry2018
General Expressions for Carr-Purcell-Meiboom-Gill Relaxation Dispersion for N-Site Chemical Exchange.
Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- NMR methods for investigating functionally relevant biomolecular dynamics.Magnetic resonance letters · 2025Review
- Ligand-induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Site-based description of RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- NMR Studies of Aromatic Ring Flips to Probe Conformational Fluctuations in Proteins.The journal of physical chemistry. B · 2023Review
- Theoretical classification of exchange geometries from the perspective of NMR relaxation dispersion.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Model-Free or Not?Frontiers in molecular biosciences · 2021Review
- Algebraic expressions for Carr-Purcell-Meiboom-Gill relaxation dispersion for N-site chemical exchange.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarizedChemical science · 2020Article
- Chemical exchange induced Hahn echo modulation in pulsed electron paramagnetic resonance experiment.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Compact expressions for RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Chemical Exchange.Methods in enzymology · 2019Article
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Abstract
The Carr-Purcell-Meiboom-Gill (CPMG) nuclear magnetic resonance experiment is widely used to characterize chemical exchange phenomena in biological macromolecules. Theoretical expressions for the nuclear spin relaxation rate constant for two-site chemical exchange during CPMG pulse trains valid for all time scales are well-known as are descriptions of N-site exchange in the fast limit. We have obtained theoretical expressions for N-site exchange outside of the fast limit by using approximations to an average Liouvillian describing the decay of magnetization during a CPMG pulse train. We obtain general expressions for CPMG experiments for any N-site scheme and all experimentally accessible time scales. For sufficiently slow chemical exchange, we obtain closed-form expressions for the relaxation rate constant and a general characteristic polynomial for arbitrary kinetic schemes. Furthermore, we highlight features that qualitatively characterize CPMG curves obtained for various N-site kinetic topologies, quantitatively characterize CPMG curves obtained from systems in various N-site exchange situations, and test distinguishability of kinetic models.
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