Evidence map›Paper›PMID 30040133›Full record

ArticleJournal of anatomy2018

Quantification of hyaluronan in human fasciae: variations with function and anatomical site.

C Fede, A Angelini, R Stern, V Macchi, A Porzionato, P Ruggieri, R De Caro, C Stecco

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of anatomy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06060925 (Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06060925 completednot on this mapstarted 2023, after this paper: background citation

Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain

TypeobservationalSponsorGeorge Mason UniversityRan2023 to 2025Enrolled96ConditionsMyofascial Pain Syndrome, HealthyArmsUltrasound imaging, Bioimpedance spectroscopy, Electromyography, Physical examination
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. The Impact of Fascial ManipulationDiagnostics (Basel, Switzerland) · 2024
    Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

C FedeDepartment of Neuroscience, University of Padua, Padua, Italy.
A AngeliniDepartment of Surgery, Oncology and Gastroenterology DiSCOG, Orthopedic Clinic, University of Padua, Padua, Italy.
R SternDivision of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA.
V MacchiDepartment of Neuroscience, University of Padua, Padua, Italy.
A PorzionatoDepartment of Neuroscience, University of Padua, Padua, Italy.
P RuggieriDepartment of Surgery, Oncology and Gastroenterology DiSCOG, Orthopedic Clinic, University of Padua, Padua, Italy.
R De CaroDepartment of Neuroscience, University of Padua, Padua, Italy.
C SteccoDepartment of Neuroscience, University of Padua, Padua, Italy.ORCID 0000-0002-8767-4555
University of Padua · ITTouro College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, alterations in fascial gliding-like movement have been invoked as critical in the etiology of myofascial pain. Various methods have been attempted for the relief of this major and debilitating clinical problem. Paramount have been attempts to restore correct gliding between fascial layers and the movement over bone, joint, and muscular structures. One of the key elements that underlies such fascial movement is hyaluronan. However, until now, the precise content of hyaluronan within fasciae has been unknown. This study quantifies for the first time the hyaluronan content of human fascial samples obtained from a variety of anatomic sites. Here, we demonstrate that the average amount varies according to anatomic site, and according to the different kinds of sliding properties of the particular fascia. For example, the fascia lata has 35 μg of hyaluronan per gram of tissue, similar to that of the rectus sheath (29 μg g

Indexed as

FasciaHumansHyaluronic AcidHyaluronic Aciddensificationextracellular matrixfasciafibrosisglidinghyaluronanmyofascial pain

Identifiers

PMID30040133
PMCPMC6131966
OpenAlexW2884694348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.