Evidence map›Paper›PMID 30040066›Full record

ArticleeLife2018

The dual role of chloride in synaptic vesicle glutamate transport.

Roger Chang, Jacob Eriksen, Robert H Edwards

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. VGLUT2 in Parkinson's disease: an emerging therapeutic target.Expert opinion on therapeutic targets · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025
    Review
  6. Review
  7. Vesicular glutamate transporters are HNature communications · 2023
    Article
  8. Article
  9. Review
  10. Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. ClAmerican journal of physiology. Cell physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Roger ChangDepartment of Physiology, UCSF School of Medicine, San Francisco, United States.ORCID 0000-0001-5654-2480
Jacob EriksenDepartment of Physiology, UCSF School of Medicine, San Francisco, United States.ORCID 0000-0003-0726-9769
Robert H EdwardsDepartment of Physiology, UCSF School of Medicine, San Francisco, United States.ORCID 0000-0002-8650-3260
University of California, San Francisco · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
PREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3M
Structural Basis of Vesicular Neurotransmitter TransportR01NS089713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H, STROUD, ROBERT M · 2015 to 2023
$5.8M
Transport of Neurotransmitter Into Synaptic VesiclesR37MH050712 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H · 2012 to 2020
$3.5M
Role of a Chloride Conductance Associated with Vesicular Glutamate TransportF31NS092298 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, ROGER C · 2015 to 2016
$71k
MOTOR CORRELATES OF ONTOGENYF32NS009229 · NINDS · INDIANA UNIVERSITY BLOOMINGTON · PI ALLAN, SUSAN E · 1992 to 1994
–
NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM008568NIH HHS 5R01 NS08971NIH HHS 5R01 NS089713NIH HHS F31 NS09229-01A1NIMH NIH HHS R37 MH050712NIMH NIH HHS R37 MH50712NINDS NIH HHS F31 NS092298NINDS NIH HHS F32 NS009229NINDS NIH HHS R01 NS089713NINDS NIH HHS T32 GM008568
6 · The paper itself

Abstract

The transport of glutamate into synaptic vesicles exhibits an unusual form of regulation by Cl

Indexed as

Adenosine TriphosphateAnimalsBiological TransportChloridesGlutamic AcidHEK293 CellsHumansRatsSynaptic VesiclesVesicular Glutamate Transport Protein 1Vesicular Glutamate Transport Protein 2Vesicular Glutamate Transport ProteinsAdenosine TriphosphateChloridesGlutamic AcidSlc17a6 protein, ratSlc17a7 protein, ratSlc17a8 protein, ratVesicular Glutamate Transport Protein 1Vesicular Glutamate Transport Protein 2Vesicular Glutamate Transport Proteinsallosteric activationchloridechloride conductanceendosome recordingmolecular biophysicsneuroscienceneurotransmitter packagingratstructural biologyvesicular glutamate transport

Identifiers

PMID30040066
PMCPMC6057745
OpenAlexW2884838797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.