Evidence map›Paper›PMID 30040063›Full record

ArticleMicrobial genomics2018

Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry.

Sion C Bayliss, David W Verner-Jeffreys, David Ryder, Rudy Suarez, Roxana Ramirez, Jaime Romero, Ben Pascoe, Sam K Sheppard, Marcos Godoy, Edward J Feil

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Whole-genome sequencing reveals a novelApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pathogens (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Atlantic Salmon Pre-smolt Survivors ofFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sion C Bayliss1​Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
David W Verner-Jeffreys2​Weymouth Laboratory, Centre for Environment, Fisheries and Aquaculture Science (Cefas), The Nothe, Weymouth, UK.
David Ryder2​Weymouth Laboratory, Centre for Environment, Fisheries and Aquaculture Science (Cefas), The Nothe, Weymouth, UK.
Rudy Suarez3​Laboratorio ETECMA, Puerto Montt, Chile.
Roxana Ramirez3​Laboratorio ETECMA, Puerto Montt, Chile.
Jaime Romero5​Laboratorio de Biotecnología, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, Chile.
Ben Pascoe1​Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
Sam K Sheppard1​Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
Marcos Godoy4​Facultad de Medicina Veterinaria, Universidad San Sebastian, Puerto Montt 5501842, Chile.
Edward J Feil1​Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, UK.
University of Bath · GBCentre for Environment, Fisheries and Aquaculture Science · GBUnited Nations Economic Commission for Latin America and the Caribbean · CLSan Sebastián University · CLUniversity of Chile · CL

Funding

Biotechnology and Biological Sciences Research Council BB/M026388/1Medical Research Council G0801929Medical Research Council MR/L015080/1
6 · The paper itself

Abstract

Renibacterium salmoninarum is the causative agent of bacterial kidney disease (BKD), which is a commercially important disease of farmed salmonids. Typing by conventional methods provides limited information on the evolution and spread of this pathogen, as there is a low level of standing variation within the R. salmoninarum population. Here, we apply whole-genome sequencing to 42 R. salmoninarum isolates from Chile, primarily from salmon farms, in order to understand the epidemiology of BKD in this country. The patterns of genomic variation are consistent with multiple introductions to Chile, followed by rapid dissemination over a 30 year period. The estimated dates of introduction broadly coincide with major events in the development of the Chilean aquaculture industry. We find evidence for significant barriers to transmission of BKD in the Chilean salmon production chain that may also be explained by previously undescribed signals of host tropism in R. salmoninarum. Understanding the genomic epidemiology of BKD can inform disease intervention and improve sustainability of the economically important salmon industry. This article contains data hosted by Microreact.

Indexed as

AquacultureAnimalsChileMicrococcaceaeMolecular EpidemiologyPhylogenySalmonSalmonidaeWhole Genome Sequencingaquaculturebacterial kidney diseaseepidemiologyRenibacterium salmoninarumwhole-genome sequencing

Identifiers

PMID30040063
PMCPMC6202448
OpenAlexW2883142431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.