ArticleInternational journal of stroke : official journal of the International Stroke Society2019
Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study.
Article in International journal of stroke : official journal of the International Stroke Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Charting neuroethics discourse in Africa: A scoping review of ethical issues of neuroscience research in Africa.IBRO neuroscience reports · 2025Article
- Growing Data science Research in Africa to Stimulate Progress (GRASP) program: Rationale and overview.Equity neuroscience · 2025Article
- Genetic testing perspectives in Pakistani population: a survey on knowledge, attitudes, awareness, and concerns.Journal of community genetics · 2024Article
- Publics' knowledge of, attitude to and motivation towards health-related genomics: a scoping review.European journal of human genetics : EJHG · 2024Article
- Perceptions and beliefs of community gatekeepers about genomic risk information in African cleft research.BMC public health · 2024Article
- Influencing factors of early activity in patients with acute ischemic stroke based on social ecological model: A qualitative study.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Attitudes towards genetic testing: The role of genetic literacy, motivated cognition, and socio-demographic characteristics.PloS one · 2023Article
- Readiness to Accept Genetic Testing for Personalized Medicine: Survey Findings on the Role of Socio-Demographic Characteristics, Health Vulnerabilities, Perceived Genetic Risk and Personality Factors.Journal of personalized medicine · 2022Article
- Article
- Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria.PloS one · 2022Article
- Stroke in Africa: profile, progress, prospects and priorities.Nature reviews. Neurology · 2021Review
- Conceptual framework for establishing the African Stroke Organization.International journal of stroke : official journal of the International Stroke Society · 2021Article
- Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans.Neurology · 2020Article
- Unraveling the Ethical, Legal, and Social Implications of Neurobiobanking and Stroke Genomic Research in Africa: A Study Protocol of the African Neurobiobank for Precision Stroke Medicine ELSI Project.International journal of qualitative methodsArticle
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61 authors at 16 institutions in 3 countries.
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Abstract
backgroundIt is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa.
objectiveTo assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies.
methodsA comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed.
resultsOnly 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25-1.81) and a family history of stroke (OR 1.20, 1.03-1.39) while Islamic religion (OR=0.82, CI: 0.72-0.94), being currently unmarried (OR = 0.81, CI: 0.70-0.92), and alcohol use (OR = 0.78, CI: 0.67-0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03-1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65-0.96).
conclusionTo further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.
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