Evidence map›Paper›PMID 30040040›Full record

ArticleRadiology2018

US Molecular Imaging of Acute Ileitis: Anti-Inflammatory Treatment Response Monitored with Targeted Microbubbles in a Preclinical Model.

Huaijun Wang, Jean-Marc Hyvelin, Stephen A Felt, Ismayil Guracar, Jose G Vilches-Moure, Samir Cherkaoui, Thierry Bettinger, Lu Tian, Amelie M Lutz, Jürgen K Willmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. E-selectin in vascular pathophysiology.Frontiers in immunology · 2024
    Review
  2. Article
  3. Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Huaijun WangFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).ORCID 0000-0003-0078-5592
Jean-Marc HyvelinFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Stephen A FeltFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Ismayil GuracarFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Jose G Vilches-MoureFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Samir CherkaouiFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Thierry BettingerFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Lu TianFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Amelie M LutzFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).
Jürgen K WillmannFrom the Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant SO62B, Stanford, CA 94305-5105 (H.W., A.M.L., J.K.W.); Bracco Suisse SA, Geneva, Switzerland (J.M.H., S.C., T.B.); Departments of Comparative Medicine (S.A.F., J.G.V.) and Health, Research & Policy (L.T.), Stanford University, Stanford, Calif; and Ultrasound Business Unit, Siemens Healthcare, Mountain View, Calif (I.G.).ORCID 0000-0003-4306-8171
Stanford University · USBracco (Switzerland) · CHSiemens Healthineers (Germany) · DE

Funding

Quantification and monitoring inflammation in IBD with Molecular UltrasoundR01DK092509 · NIDDK · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2012 to 2016
$2.4M
NIDDK NIH HHS R01 DK092509
6 · The paper itself

Abstract

Purpose To evaluate whether dual-selectin-targeted US molecular imaging allows longitudinal monitoring of anti-inflammatory treatment effects in an acute terminal ileitis model in swine. Materials and Methods The Institutional Animal Care and Use Committee approved all animal studies. Fourteen swine with chemically induced acute terminal ileitis (day 0) were randomized into the following groups: (a) an anti-inflammatory treatment group (n = 8; meloxicam, 0.25 mg per kilogram of body weight; prednisone, 0.5 mg/kg) and (b) a control group (n = 6; saline). US molecular imaging was performed with a clinical US machine after intravenous injection of clinically translatable dual P- and E-selectin-targeted microbubbles (5 × 10

Indexed as

AnimalsAnti-Inflammatory AgentsDrug MonitoringIleitisMicrobubblesMolecular ImagingSwineAnti-Inflammatory Agents

Identifiers

PMID30040040
PMCPMC6190483
OpenAlexW2883914778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.