Evidence map›Paper›PMID 30040038›Full record

ArticleRadiology2018

Quantitative Susceptibility MRI to Detect Brain Iron in Amyotrophic Lateral Sclerosis.

Julio Acosta-Cabronero, Judith Machts, Stefanie Schreiber, Susanne Abdulla, Katja Kollewe, Susanne Petri, Nicola Spotorno, Joern Kaufmann, Hans-Jochen Heinze, Reinhard Dengler and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  16. New developments in imaging in ALS.Journal of neurology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Julio Acosta-CabroneroFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).ORCID 0000-0003-1174-5983
Judith MachtsFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Stefanie SchreiberFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Susanne AbdullaFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Katja KolleweFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Susanne PetriFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Nicola SpotornoFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Joern KaufmannFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Hans-Jochen HeinzeFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Reinhard DenglerFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Stefan VielhaberFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Peter J NestorFrom the German Center for Neurodegenerative Diseases, Magdeburg, Germany (J.A., J.M., N.S., H.J.H., P.J.N.); Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, England (J.A.); Department of Neurology, Otto von Guericke University, Magdeburg, Germany (J.M., S.S., S.A., J.K., H.J.H., S.V.); Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany (S.A., K.K., S.P., R.D.); Leibniz Institute for Neurobiology, Magdeburg, Germany (H.J.H.); and Queensland Brain Institute, University of Queensland, Brisbane, Australia (P.J.N.).
Wellcome Centre for Human Neuroimaging · GBThe University of Queensland · AU

Funding

Wellcome TrustWellcome Trust 203147/Z/16/Z
6 · The paper itself

Abstract

Purpose To investigate the whole-brain landscape of iron-related abnormalities in amyotrophic lateral sclerosis (ALS) by using the in vivo MRI technique of quantitative susceptibility mapping (QSM). Materials and Methods For this prospective study, 28 patients with ALS (mean age, 61 years; age range, 43-77 years; 18 men [mean age, 61 years; range, 43-77 years] and 10 women [mean age, 61 years; range, 47-74 years]) recruited between January 17, 2014, and September 4, 2015, and 39 matched control subjects (mean age, 61 years; age range, 39-77 years; 24 men [mean age, 62 years; range, 39-77 years] and 15 women [mean age, 59 years; range, 39-73 years]) were examined by using structural and susceptibility 3.0-T MRI techniques. Group data were cross sectionally compared with family-wise error (FWE) corrections by using voxel-based morphometry (random-field theory), cortical thickness analysis (Monte Carlo simulated), subcortical volumetry (Bonferroni-corrected Wilcoxon rank-sum testing), and QSM analysis (cluster-enhanced whole-brain permutation testing and Bonferroni-corrected rank-sum testing in regions of interest). In patients with ALS, a potential relationship between diffusion and susceptibility measurements in the corticospinal tracts (CSTs) was also examined by using Spearman rank-correlation tests. Results Conventional structural measures failed to identify atrophy in the present cohort (FWE P > .05). However, QSM identified several whole-brain abnormalities (FWE P < .05) in ALS. Regionally, higher susceptibility (expressed as means in parts per million ± standard errors of the mean) was confirmed in the motor cortex (ALS = 0.0188 ± 0.0003, control = 0.0173 ± 0.0003; P < .001), the left substantia nigra (ALS = 0.127 ± 0.004, control = 0.113 ± 0.003; P = .008), the right substantia nigra (ALS = 0.141 ± 0.005, control = 0.120 ± 0.003; P < .001), the globus pallidus (ALS = 0.086 ± 0.003, control = 0.075 ± 0.002; P = .003), and the red nucleus (ALS = 0.115 ± 0.004, control = 0.098 ± 0.003; P < .001). Lower susceptibility was found in CST white matter (ALS = -0.047 ± 0.001, control = -0.043 ± 0.001; P = .01). Nigral and pallidal QSM values were cross correlated in ALS (ρ

Indexed as

AdultAgedAmyotrophic Lateral SclerosisBrainBrain ChemistryFemaleHumansImage Interpretation, Computer-AssistedIronMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesIron

Identifiers

PMID30040038
PMCPMC6166868
OpenAlexW2883772201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.