Evidence map›Paper›PMID 30039967›Full record

ArticleAnalytical chemistry2018

Comprehensive Regression Model for Dissociation Equilibria of Cell-Specific Aptamers.

Yifan Lyu, I-Ting Teng, Liqin Zhang, Yian Guo, Ren Cai, Xiaobing Zhang, Liping Qiu, Weihong Tan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yifan LyuInstitute of Molecular Medicine, Renji Hospital, School of Medicine and College of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.
I-Ting TengDepartment of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Inter-face, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute , University of Florida , Gainesville , Florida 32611-7200 , United States.
Liqin ZhangMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , People's Republic of China.ORCID 0000-0002-3632-4117
Yian GuoDepartment of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Inter-face, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute , University of Florida , Gainesville , Florida 32611-7200 , United States.
Ren CaiMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , People's Republic of China.
Xiaobing ZhangMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , People's Republic of China.
Liping QiuMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , People's Republic of China.
Weihong TanInstitute of Molecular Medicine, Renji Hospital, School of Medicine and College of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.ORCID 0000-0002-8066-1524
Hunan University · CNUniversity of Florida · US

Funding

Aptamer Engineering: From Molecule to MedicineR35GM127130 · NIGMS · UNIVERSITY OF FLORIDA · PI TAN, WEIHONG · 2018 to 2018
$328k
NIGMS NIH HHS R35 GM127130
6 · The paper itself

Abstract

A comprehensive nonlinear regression model for dissociation equilibria of cell-specific aptamers is proposed by considering the effect of receptor expression level. Benefiting from the global regression of simultaneous equations, the fitted parameters reach a very significant level, indicating the statistical validity of this updated model. According to the fitting results, we found that dissociation constants fitted using the previous model are obviously larger than the updated values, which can be explained by the effect of receptor number on curve fitting. In addition, equivalent receptor density can be estimated using the updated model, which may lead to some new judgments about reported results of cell-SELEX.

Indexed as

Models, StatisticalAptamers, NucleotideCell Line, TumorHumansModels, TheoreticalReproducibility of ResultsSELEX Aptamer TechniqueAptamers, Nucleotide

Identifiers

PMID30039967
PMCPMC6522138
OpenAlexW2883722336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.