Evidence map›Paper›PMID 30039863›Full record

ArticleJournal of medical primatology2018

Papio spp. Colon microbiome and its link to obesity in pregnancy.

XuanJi Li, Christopher Rensing, William L Taylor, Caitlin Costelle, Asker Daniel Brejnrod, Robert J Ferry, Paul B Higgins, Franco Folli, Kameswara Rao Kottapalli, Gene B Hubbard and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

XuanJi LiDepartment of Biology, University of Copenhagen, Universitetsparken, Denmark.
Christopher RensingInstitute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
William L TaylorMolecular Resource Center, University of Tennessee Health Science Center, Memphis, Tennessee.
Caitlin CostelleMolecular Resource Center, University of Tennessee Health Science Center, Memphis, Tennessee.
Asker Daniel BrejnrodDepartment of Biology, University of Copenhagen, Universitetsparken, Denmark.
Robert J FerryPsychology Department, University of Memphis, Memphis, Tennessee.
Paul B HigginsTexas Biomedical Research Institute, San Antonio, Texas.
Franco FolliEndocrinology and Metabolism, Department of Health Science, University of Milano and ASST Santi Paolo e Carlo, Milano, Italy.
Kameswara Rao KottapalliCenter for Biotechnology and Genomics, Texas Tech University, Lubbock, Texas.
Gene B HubbardUniversity of Texas Health Sciences Center at San Antonio, San Antonio, Texas.
Edward J DickTexas Biomedical Research Institute, San Antonio, Texas.
Shibu YoosephJ. Craig Venter Institute, La Jolla, California.
Karen E NelsonJ. Craig Venter Institute, La Jolla, California.
Natalia Schlabritz-LoutsevitchDepartment of Obstetrics and Gynecology, College of Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas.ORCID 0000-0002-9868-7490

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GAUDUIN, MARIE-CLAIRE ELISABETH · 1999 to 2011
$79.1M
PARTURITION AND FETAL PRIMATE HYPOTHALAMIC FUNCTIONP01HD021350 · NICHD · UNIVERSITY OF WYOMING · PI COX, LAURA A · 1987 to 2018
$19.9M
EXTRAMURAL RES FACILITIES CONSTRC06RR015456 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 2001 to 2001
$1.1M
BABOON F-CAGE FACILITY FOR PRIMATE RESEARCH CENTERC06RR014578 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1999 to 1999
–
NCRR NIH HHS C06 RR014578NCRR NIH HHS C06 RR015456NCRR NIH HHS P51 RR013986NICHD NIH HHS P01 HD021350NIH HHS P51 OD011133
6 · The paper itself

Abstract

introductionGut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. MATERIAL AND

methodsBanked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test.

resultsThree families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups.

conclusionChanges in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaFemaleMonkey DiseasesObesityPapioPregnancybaboonmicrobiomeobesitypregnancy

Identifiers

PMID30039863
PMCPMC6430121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.