ArticleeLife2018
Neurexin directs partner-specific synaptic connectivity in
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In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
–field-weighted citation impact
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Who cites it
43 citing papers in PubMed.
- Intracellular regulation of a serotonin-gated ion channel links receptor trafficking to memory.iScience · 2026Article
- The contactin rig-6 transiently promotes GABA neuron remodeling with a sustained impact on male mating behavior in C. elegans.Genetics · 2026Article
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- Transcriptome profiling of neurexin- and neuroligin-deficient Caenorhabditis elegans reveals pathways underlying developmental and behavioral dysfunction.Research square · 2026Article
- Roles of synaptic cell adhesion molecules in the neuromodulatory systems.Molecules and cells · 2026Review
- Transsynaptic linking of calcium channels and postsynaptic receptors at a dyadic synapse.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-wide analysis reveals pathways important for the development and maturation of excitatory synaptic connections to GABAergic neurons.G3 (Bethesda, Md.) · 2026Article
- Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.bioRxiv : the preprint server for biology · 2025Article
- Insertion of rare autism variants in synaptic genes induce novel behavioral phenotypes inbioRxiv : the preprint server for biology · 2025Article
- Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity.Ibrain · 2025Review
- Conserved autism-associated genes tune social feeding behavior in C. elegans.Nature communications · 2024Article
- Neural Circuit Remodeling: Mechanistic Insights from Invertebrates.Journal of developmental biology · 2024Review
- UNC-30/PITX coordinates neurotransmitter identity with postsynaptic GABA receptor clustering.Development (Cambridge, England) · 2024Article
- Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin.G3 (Bethesda, Md.) · 2024Article
- Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly.PLoS biology · 2024Article
- The extracellular matrix molecule Collagen XVIII/CLE-1 affects neuronal dendritic spines.microPublication biology · 2024Article
- Conserved autism-associated genes tune social feeding behavior inbioRxiv : the preprint server for biology · 2023Article
- Distinct neurexin isoforms cooperate to initiate and maintain foraging activity.Translational psychiatry · 2023Article
- The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling.Nature communications · 2023Article
- Protein-lipid interactions drive presynaptic assembly upstream of cell adhesion molecules.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Alison PhilbrookDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0003-3330-3086
Shankar RamachandranDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.
Christopher M LambertDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.
Devyn OliverDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.
Jeremy FlormanDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-7578-3511
Mark J AlkemaDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.
Michele LemonsDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.
Michael M FrancisDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-8076-6668
Funding
Molecular Analysis of Neural Circuit Excitation and InhibitionR01NS064263 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRANCIS, MICHAEL M · 2009 to 2025
$5.5MMolecular and neuronal mechanisms of complex behaviorsR01GM084491 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK · 2008 to 2017
$3.0MThe impact of stress neurohormones on health and agingR01GM140480 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK · 2021 to 2024
$1.5MMolecular regulation of nicotinic acetylcholine receptorsF31DA038399 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PHILBROOK, ALISON · 2015 to 2017
$91kNIDA NIH HHS F31 DA038399NIDA NIH HHS F31DA038399NIGMS NIH HHS R01 GM084491NIGMS NIH HHS R01GM084491NIGMS NIH HHS R01 GM140480NINDS NIH HHS R01 NS064263NINDS NIH HHS R01NS064263
Abstract
In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these divergent connections are generated, using dyadic synapses in
Indexed as
Synaptic TransmissionAcetylcholineAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell Adhesion Molecules, NeuronalGABAergic NeuronsNeuromuscular JunctionReceptors, CholinergicReceptors, NicotinicSynapsesAcetylcholineCaenorhabditis elegans ProteinsCell Adhesion Molecules, Neuronalnrx-1 protein, C elegansReceptors, CholinergicReceptors, NicotinicAChRC. elegansdendritic spineneuroscienceneurotransmissionnicotinic acetylcholine receptorsynapsesynaptic divergence
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.