Evidence map›Paper›PMID 30039728›Full record

ArticleMolecular imaging

Detecting Demyelination by PET: The Lesion as Imaging Target.

Pedro Brugarolas, Daniel S Reich, Brian Popko

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Synthesis of KBioorganic & medicinal chemistry letters · 2024
    Article
  3. Article
  4. Radiochemical Synthesis and Evaluation of 3-[ACS chemical neuroscience · 2022
    Article
  5. Article
  6. Evaluation of the potassium channel tracer [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Pedro Brugarolas1 Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Daniel S Reich2 Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Brian Popko3 Department of Neurology, University of Chicago, Chicago, IL, USA.
Gordon Center for Medical Imaging · USNational Institutes of Health · USUniversity of Chicago · US

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Fluorinated 4-Aminopyridines for Therapy and Diagnosis of Multiple SclerosisR21NS084382 · NINDS · UNIVERSITY OF CHICAGO · PI POPKO, BRIAN J · 2014 to 2015
$435k
New tools for imaging: diagnostics based on therapeuticsK99EB020075 · NIBIB · UNIVERSITY OF CHICAGO · PI BRUGAROLAS, PEDRO · 2015 to 2016
$167k
NIBIB NIH HHS K99 EB020075NINDS NIH HHS R21 NS084382
6 · The paper itself

Abstract

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al's study

Indexed as

AnimalsAxonsDemyelinating DiseasesHumansMagnetic Resonance ImagingPositron-Emission TomographyPotassium ChannelsPotassium Channelsadvances in PET/SPECT probesimaging in neurosciencemolecular imaging of neuro-degenerative diseases

Identifiers

PMID30039728
PMCPMC6058413
OpenAlexW2884874990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.