Evidence map›Paper›PMID 30039435›Full record

ArticleEuropean journal of nutrition2019

Association of macronutrient consumption with arterial aging in adults without clinically overt cardiovascular disease: a 5-year prospective cohort study.

G Georgiopoulos, K Karatzi, E Euthimiou, A Laina, C Kontogiannis, A Mareti, I Mavroeidis, A Kouzoupis, A Mitrakou, C Papamichael and 1 more

Abstract read
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In one paragraph

Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

G GeorgiopoulosVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
K KaratziDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou str, 17671, Athens, Greece.
E EuthimiouVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
A LainaVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
C KontogiannisVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
A MaretiVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
I MavroeidisVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
A KouzoupisMedical School, First Psychiatric Clinic, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
A MitrakouVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
C PapamichaelVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece.
Kimon StamatelopoulosVascular Laboratory, Department of Clinical Therapeutics, Medical School, Alexandra University Hospital, National and Kapodistrian University of Athens, 80 Vas. Sofias Str, 11528, Athens, Greece. stamatelopoulosk@yahoo.gr.
National and Kapodistrian University of Athens · GRAlexandra Hospital · GREginition Hospital · GRHarokopio University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is limited and inconsistent evidence regarding longitudinal effects of macronutrients on blood pressure (BP) haemodynamics and arterial aging in populations without cardiovascular disease (CVD). We aimed to prospectively investigate potential association of dietary macronutrients with long-term changes in peripheral and central haemodynamics and arterial stiffness.

methodsOne hundred and fifteen subjects (46.7 ± 8.73 years, 70 women), free of clinically overt CVD were consecutively recruited. Dietary macronutrient intake was evaluated using 3-day food records at baseline. Aortic stiffness and arterial wave reflections were assessed at baseline and in one follow-up visit 5 years later by pulse wave velocity (PWV) and augmentation index (AI), respectively.

resultsIndividuals with the highest consumption of saturated fatty acids (SFA) presented the highest rate of progression in PWV, AI and aortic diastolic BP (p < 0.05 for all) after adjustment for age, gender, smoking, body mass index, hyperlipidemia, insulin resistance, changes in systolic BP and treatment with antihypertensive and hypolipidemic drugs. After similar multivariable adjustments, high consumption of carbohydrates was associated with higher progression of AI, whereas high consumption of monounsaturated fatty acids (MUFA) and fibre with lower progression in aortic and peripheral systolic and diastolic BP (p < 0.05 for all).

conclusionsIn subjects without CVD, high consumption of SFA is related to accelerated arterial stiffening, while high consumption of MUFA and fibre and low intake of carbohydrates is associated with attenuated progression in blood pressure and arterial wave reflections, respectively. These findings expand current knowledge on the association of macronutrient consumption with arterial aging in the general population.

Indexed as

AgingArteriesBlood PressureCohort StudiesFemaleHemodynamicsHumansMaleMiddle AgedNutrientsProspective StudiesPulse Wave AnalysisRisk FactorsVascular StiffnessNutrientsArterial stiffnessCarbohydratesFatty acidsFibreHaemodynamicsMonounsaturated fatty acids

Identifiers

PMID30039435
OpenAlexW2884646453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.