Evidence map›Paper›PMID 30039390›Full record

ArticleVirchows Archiv : an international journal of pathology2018

Small oral tongue cancers (≤ 4 cm in diameter) with clinically negative neck: from the 7th to the 8th edition of the American Joint Committee on Cancer.

Alhadi Almangush, Antti A Mäkitie, Laura K Mäkinen, Joonas H Kauppila, Matti Pukkila, Jaana Hagström, Jussi Laranne, Ylermi Soini, Luiz Paulo Kowalski, Reidar Grénman and 4 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. The updated AJCC/TNM staging system (8Translational cancer research · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alhadi AlmangushDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland. alhadi.almangush@helsinki.fi.
Antti A MäkitieDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Laura K MäkinenDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Joonas H KauppilaCancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
Matti PukkilaDepartment of Otorhinolaryngology and Head and Neck Surgery, Kuopio University Hospital, Kuopio, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland.
Jussi LaranneDepartment of Otorhinolaryngology and Head and Neck Surgery, Tampere University Hospital, Tampere, Finland.
Ylermi SoiniDepartment of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
Luiz Paulo KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, -SP, Brazil.
Reidar GrénmanDepartment of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, University of Turku, Turku, Finland.
Caj HaglundResearch Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.
Ricardo D ColettaDepartment of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
Tuula SaloDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland.
Ilmo LeivoDepartment of Pathology, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the main changes in the 8th edition of the American Joint Committee on Cancer (AJCC) for staging of oral cancer is the inclusion of depth of invasion (DOI) in the T category. However, cancers in different oral subsites have variable behavior, with oral tongue squamous cell carcinoma (OTSCC) being the most aggressive one even at early stage. Thus, it is necessary to evaluate the performance of this new T category in homogenous cohort of early OTSCC. Therefore, we analyzed a large cohort of patients with a small (≤ 4 cm) OTSCC to demonstrate the differences in T stage between the AJCC 7th and 8th editions. A total of 311 early-stage cases (AJCC 7th) of OTSCC were analyzed. We used 5 mm and 10 mm DOI for upstaging from T1 to T2 and from T2 to T3 respectively, as in the AJCC 8th. We further reclassified the cases according to our own proposal suggesting 2 mm to upstage to T2 and 4 mm to upstage to T3. According to AJCC 7th, there were no significant differences in the survival analysis. When we applied the 8th edition, many cases were upstaged to T3 and thus associated with worse disease-specific survival (HR 2.37, 95% CI 1.12-4.99) and disease-free survival (HR 2.12, 95% CI 1.09-4.08). Based on our proposal, T3 cases were associated with even worse disease-specific survival (HR 4.19, 95% CI 2.27-7.74). The 8th edition provides better survival prediction for OTSCC than the 7th and can be further optimized by lowering the DOI cutoffs.

Indexed as

Tumor BurdenCarcinoma, Squamous CellDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleNeoplasm InvasivenessNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsReproducibility of ResultsRetrospective StudiesRisk FactorsSquamous Cell Carcinoma of Head and Neck7th AJCC8th AJCCDepth of invasionEarly-stageOral tongue cancer

Identifiers

PMID30039390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.