ReviewUpdates in surgery2018
Pathophysiology of gastroesophageal reflux disease: how an antireflux procedure works (or does not work).
Review in Updates in surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Efficacy and Safety of Fundoplication Sleeve Gastrectomy in Obesity and GERD: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Endoscopic therapy with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease: a case description.Quantitative imaging in medicine and surgery · 2025Article
- Use of intraoperative fluoroscopy to reduce post-peroral endoscopic myotomy reflux: a proof-of-concept study.iGIE : innovation, investigation and insights · 2025Article
- The short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease.BMC gastroenterology · 2025Observational
- High-resolution 3-dimensional tomography may be a useful tool for understanding the anatomy of hiatal hernias and surgical planning of patients eligible for laparoscopic or robotic antireflux surgery.Surgical endoscopy · 2024Article
- Preoperative measurement of the hiatal surface with MDCT: impact on surgical planning.La Radiologia medica · 2021Article
- Gastroesophageal Reflux Disease, Obesity, and Roux-en-Y Gastric Bypass: Complex Relationship-a Narrative Review.Obesity surgery · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of gastroesophageal reflux disease is complex and linked to an intricate valve mechanism at the level of the esophagogastric junction that must counteract a trans-diaphragmatic pressure gradient, which is constantly forcing gastric contents upwards. Surgical antireflux therapy is usually aimed towards reinforcement of this valve mechanism. The valve mechanism is made up by the intra-abdominal length of the esophagus; the diaphragmatic sphincter, the angle of His, and the lower esophageal sphincter: all these elements must be restored with an antireflux procedure. Hiatal approximation and fundoplication determine excellent outcomes in patients in whom the abnormal reflux is mostly due to the valve mechanism. In patients with altered intra-abdominal pressure due to obesity, a bariatric procedure such as a Roux-en-Y gastric bypass is probably more appropriate. For patients with an altered intra-thoracic pressure such as in idiopathic pulmonary fibrosis, a fundoplication has been shown to be beneficial in resolving symptoms and avoiding progression of the diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.