ArticleTaiwan journal of ophthalmology
Investigation of methylenetetrahydrofolate reductase C677T and factor V Leiden mutation as a genetic marker for retinal vein occlusion.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- To Study the Role of Serum Homocysteine Levels and Ocular Involvement in Retinal Vasculitis.Indian journal of clinical biochemistry : IJCB · 2022Article
- Mapping research trends of retinal vein occlusion from 2009 to 2018: a bibliometric analysis.PeerJ · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
purposeThromboembolic phenomenon is one of the causes of retinal vein occlusion (RVO) which is in fact a multifactorial disease. Therefore, we aimed to study methylenetetrahydrofolate reductase gene polymorphism (MTHFR C677T) and factor V Leiden as genetic risk factors of RVO. MATERIALS AND
methodsA total of 50 (19 males and 31 females) cases of RVO were compared with 50 age- and sex-matched (21 males and 29 females) controls. Complete ocular examination was done for all samples. The diagnosis of RVO was made clinically; however, fundus fluorescein angiography and optical coherence tomography were performed when needed. Serum homocysteine levels were estimated by automatic chemiluminescence analyzer, whereas MTHFR C677T and factor V Leiden mutations were detected by polymerase chain reaction-restriction fragment length polymorphism method.
resultsThe mean age of RVO cases and controls was 54.62 ± 13.92 years and 58.72 ± 11.20 years, respectively. 48.3% of cases and 51.7% of controls were diabetic. 65.3% of cases were hypertensive proving hypertension as a strong risk factor (
conclusionHyperhomocysteinemia is an important risk factor for RVO, especially in patients with MTHFR C677T gene polymorphism.
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