ArticleBone research2018
Ciliary parathyroid hormone signaling activates transforming growth factor-β to maintain intervertebral disc homeostasis during aging.
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Article in Bone research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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54 citing papers in PubMed, 78 citations in OpenAlex.
- The role of sleep and circadian rhythms in intervertebral disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Decoding intervertebral disc degeneration pathomechanics: from mechanisms to therapeutic horizons.Journal of advanced research · 2026Review
- Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain.Bone research · 2026Article
- Targeting AMPK signaling in nucleus pulposus cells ameliorates spaceflight microgravity-induced intervertebral disc degeneration.Cell death and differentiation · 2026Article
- The primary cilium at the helm: gatekeeper of TGF-β superfamily signaling in development, homeostasis, and disease.Biochemical Society transactions · 2026Review
- Exogenous parathyroid hormone (1-34) attenuates knee osteoarthritis in mice through activating the TGF-β/Smad signaling pathway.Hormones (Athens, Greece) · 2026Article
- PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice.Bone research · 2026Article
- Mechanotransduction in intervertebral disc degeneration: from compartment-specific sensors to translational frontiers.Frontiers in bioengineering and biotechnology · 2026Review
- IFT88/Kindlin-2 Signaling Prevents Mechanical Overloading-Induced PANoptosis of Nucleus Pulposus Cells by Activating FOXP1 SUMOylation.International journal of biological sciences · 2026Article
- From mechanotransduction to manual therapy: advances in piezo/TRP channels and lumbar degeneration.Frontiers in physiology · 2026Review
- Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats.JOR spine · 2025Article
- Stem cell therapy for intervertebral disc degeneration: Clinical progress with exosomes and gene vectors.World journal of stem cells · 2025Review
- Role of macrophage in intervertebral disc degeneration.Bone research · 2025Review
- Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from anFrontiers in physiology · 2025Article
- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential.Military Medical Research · 2024Review
- Assessment of the Concentration of Transforming Growth Factor Beta 1-3 in Degenerated Intervertebral Discs of the Lumbosacral Region of the Spine.Current issues in molecular biology · 2024Article
- Osteoporosis treatments for intervertebral disc degeneration and back pain: a perspective.JBMR plus · 2024Article
- Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine.Frontiers in cell and developmental biology · 2024Article
- Roles of organokines in intervertebral disc homeostasis and degeneration.Frontiers in endocrinology · 2024Review
- Review
Corrections and comments
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Authors and funding
28 authors at 7 institutions in 3 countries.
Liwei Zheng *1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Yong Cao *1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Shuangfei Ni *1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Huabin Qi1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Zemin Ling1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Xin Xu1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Xuenong Zou5Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tianding Wu1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Ruoxian Deng1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Bo Hu1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Bo Gao1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Hao Chen1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Yusheng Li1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Jianxi Zhu1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Francis Tintani1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Shadpour Demehri7The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Amit Jain1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Khaled M Kebaish1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Shenghui Liao8Faculty of Computer Science, College of Information Science and Engineering, Xiangya Hospital, Central South University, Changsha, China.
Cheryle A Séguin9Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON Canada.
Janet L Crane1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Mei Wan1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Hongbin Lu10Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China.
Paul D Sponseller1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Lee H Riley1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Xuedong Zhou2State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jianzhong Hu3Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China.
Xu Cao1Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 229, 720 Rutland Ave, Baltimore, MD USA.
Johns Hopkins Medicine · USJohns Hopkins University · USCentral South University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNSichuan University · CNWestern University · CAXiangya Hospital Central South University · CN
Funding
Interdepartmental Training Program in Cellular and Molecular EndocrinologyT32DK007751 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WOLFE, ANDREW M · 1997 to 2016
$4.6MTrap+ Mononuclear Cells in Periosteal Bone FormationR01AR071432 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2017 to 2021
$2.2MTGF-beta Activity in the Subchondral Bone and Onset of OAR01AR063943 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2013 to 2017
$2.2MNIAMS NIH HHS R01 AR063943NIAMS NIH HHS R01 AR071432NIDDK NIH HHS T32 DK007751
Abstract
Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor (PTH1R) to the cilia and enhances parathyroid hormone (PTH) signaling in NP cells. PTH induces transcription of integrin α
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