ReviewDrugs in context2018
Febrile seizures: an overview.
Review in Drugs in context, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures
Value of Von Willebrand Factor and Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 253 citations in OpenAlex.
- The non-clinical burden of febrile seizures: a systematic review.Frontiers in pediatrics · 2024Pooled it
- Fever After Influenza, Diphtheria-Tetanus-Acellular Pertussis, and Pneumococcal Vaccinations.Pediatrics · 2020Trial
- Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Febrile seizure during the acute phase of Kawasaki disease: a Korean nationwide cohort study.European journal of pediatrics · 2026Article
- Article
- Evaluation of serum and cerebrospinal fluid copeptin as biomarkers in children with febrile seizures, febrile illness without seizures, and meningitis: an exploratory study.BMC pediatrics · 2026Article
- Risk Factors Associated With Febrile Seizures in Young Children: Clinical, Biochemical, and Genetic Perspectives.Cureus · 2026Article
- Recurrence of febrile convulsions in children treated with intermittent benzodiazepines: a retrospective study investigating predisposing factors.BMC pediatrics · 2026Article
- Pioneering ultrastructural texture analysis of dendrites in the cerebellar dentate nucleus: an experimental rat model of hyperthermia-induced seizures.Scientific reports · 2026Article
- Diagnostic utility of circulating interleukin-1 beta and microRNA-146a in differentiating febrile seizures from other pediatric conditions.World journal of experimental medicine · 2026Article
- Strategic Governance of Artificial Intelligence-Enabled Clinical Algorithm Development: Formative Evaluation of the Semiautomatic Clinical Algorithm Development Framework.JMIR formative research · 2026Article
- Febrile Seizures in an App-Based Children's Fever Registry: Mixed Methods Study.JMIR pediatrics and parenting · 2026Article
- Immediate and delayed effects of thermal stress on fever-associated seizures in children: A time-stratified case-crossover study in Japan.International journal of biometeorology · 2026Article
- Article
- Risk Factors for Initial Febrile Seizures in Pediatric Patients at Iranian Tertiary Hospitals (2019-2021): Retrospective Cross-Sectional Study.Iranian journal of child neurology · 2026Article
- The genotypic spectrum of complex febrile seizures: insights from high-risk population genetic screening in a pediatric cohort.Frontiers in neuroscience · 2026Article
- Study of Clinico-Etiological Profile of New-Onset Seizure in Infants.Journal of pharmacy & bioallied sciences · 2025Article
- Article
- Febrile Seizures and Sudden Death Risk: A Case-Control Analysis.Pediatric neurology · 2025Article
- Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model.Aging and disease · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFebrile seizures are the most common neurologic disorder in childhood. Physicians should be familiar with the proper evaluation and management of this common condition.
objectiveTo provide an update on the current understanding, evaluation, and management of febrile seizures.
methodsA PubMed search was completed in Clinical Queries using the key terms 'febrile convulsions' and 'febrile seizures'. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews.
resultsFebrile seizures, with a peak incidence between 12 and 18 months of age, likely result from a vulnerability of the developing central nervous system to the effects of fever, in combination with an underlying genetic predisposition and environmental factors. The majority of febrile seizures occur within 24 hours of the onset of the fever. Febrile seizures can be simple or complex. Clinical judgment based on variable presentations must direct the diagnostic studies which are usually not necessary in the majority of cases. A lumbar puncture should be considered in children younger than 12 months of age or with suspected meningitis. Children with complex febrile seizures are at risk of subsequent epilepsy. Approximately 30-40% of children with a febrile seizure will have a recurrence during early childhood. The prognosis is favorable as the condition is usually benign and self-limiting. Intervention to stop the seizure often is unnecessary.
conclusionContinuous preventative antiepileptic therapy for the prevention of recurrent febrile seizures is not recommended. The use of intermittent anticonvulsant therapy is not routinely indicated. Antipyretics have no role in the prevention of febrile seizures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.