ArticleFrontiers in microbiology2018
Influenza Virus Segment Composition Influences Viral Stability in the Environment.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How long do pathogens persist and survive in water? A systematic review.Frontiers in microbiology · 2025Pooled it
- Filamentous morphology of influenza A virus confers enhanced stability in aerosols.Nature communications · 2026Article
- Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike.Communications biology · 2025Article
- Article
- Hemagglutinin glycosylation pattern-specific effects: implications for the fitness of H9.4.2.5-branched H9N2 avian influenza viruses.Emerging microbes & infections · 2024Article
- Investigation of SARS-CoV-2 RNA contamination in water supply resources of Tabriz metropolitan during a peak of COVID-19 pandemic.Sustainable water resources management · 2023Article
- Exploring surface water as a transmission medium of avian influenza viruses - systematic infection studies in mallards.Emerging microbes & infections · 2022Article
- Relationship between hemagglutinin stability and influenza virus persistence after exposure to low pH or supraphysiological heating.PLoS pathogens · 2021Article
- Review
- Cell-Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Airborne Transmission in Ferret Model.Viruses · 2021Article
- Natural and Experimental Persistence of Highly Pathogenic H5 Influenza Viruses in Slurry of Domestic Ducks, with or without Lime Treatment.Applied and environmental microbiology · 2020Article
- Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential.Journal of virology · 2020Article
- HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets.eLife · 2020Article
- Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase.Archives of virology · 2020Article
- Structural restrictions for influenza neuraminidase activity promote adaptation and diversification.Nature microbiology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transmission routes of Influenza A viruses (IAVs) submit virus particles to a wide range of environmental conditions that affect their transmission. In water, temperature, salinity, and pH are important factors modulating viral persistence in a strain-dependent manner, and the viral factors driving IAV persistence remain to be described. We used an innovative method based on a real-time cell system analysis to quantify viral decay in an environmental model. Thus, we identified the viral hemagglutinin (HA) and neuraminidase (NA) as the main proteins driving the environmental persistence by comparing the inactivation slopes of several reassortant viruses. We also introduced synonymous and non-synonymous mutations in the HA or in the NA that modulated IAV persistence. Our results demonstrate that HA stability and expression level, as well as calcium-binding sites of the NA protein, are molecular determinants of viral persistence. Finally, IAV particles could not trigger membrane fusion after environmental exposure, stressing the importance of the HA and the NA for environmental persistence.
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