Evidence map›Paper›PMID 30038575›Full record

ArticleFrontiers in physiology2018

Age-Related Differential Structural and Transcriptomic Responses in the Hypertensive Heart.

Francine Z Marques, Po-Yin Chu, Mark Ziemann, Antony Kaspi, Helen Kiriazis, Xiao-Jun Du, Assam El-Osta, David M Kaye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  5. Platelet Function in Aging.Frontiers in cardiovascular medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Francine Z MarquesHeart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Po-Yin ChuHeart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Mark ZiemannEpigenetics in Human Health and Disease, Department of Diabetes, Monash University, Melbourne, VIC, Australia.
Antony KaspiEpigenetics in Human Health and Disease, Department of Diabetes, Monash University, Melbourne, VIC, Australia.
Helen KiriazisExperimental Cardiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Xiao-Jun DuExperimental Cardiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Assam El-OstaEpigenetics in Human Health and Disease, Department of Diabetes, Monash University, Melbourne, VIC, Australia.
David M KayeHeart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Monash University · AUBaker Heart and Diabetes Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While aging is a critical risk factor for heart failure, it remains uncertain whether the aging heart responds differentially to a hypertensive stimuli. Here we investigated phenotypic and transcriptomic differences between the young and aging heart using a mineralocorticoid-excess model of hypertension. Ten-week ("young") and 36-week ("aging") mice underwent a unilateral uninephrectomy with deoxycorticosterone acetate (DOCA) pellet implantation (

Indexed as

agingfibrosisheart failuremicroRNAsmiRNAsmiRspathwaystranscriptome

Identifiers

PMID30038575
PMCPMC6046461
OpenAlexW2808410818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.