ArticlePaediatrics & child health2018
Antibiotic exposure and development of necrotizing enterocolitis in very preterm neonates.
Article in Paediatrics & child health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association between early postnatal antibiotic exposure and bronchopulmonary dysplasia in very preterm infants: a meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Role of complete blood count in the diagnosis of culture-proven neonatal sepsis: a systematic review and meta-analysis.Archives of disease in childhood · 2025Pooled it
- Association of initial empirical antibiotic therapy with increased risk of necrotizing enterocolitis.European journal of pediatrics · 2020Pooled it
- Effect of early antibiotic exposure on necrotizing enterocolitis and growth in extremely preterm infants.Pediatric research · 2025Trial
- Trial
- Evaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study.BMC pregnancy and childbirth · 2026Observational
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Early antibiotic exposure and necrotizing enterocolitis among preterm infants < 34 weeks' gestation.Pediatric research · 2025Article
- The double-edged sword of early antibiotic exposure in extremely preterm infants: implications for necrotizing enterocolitis and growth faltering.Pediatric research · 2025Article
- Intestinal Biomarkers in Preterm Infants: Influence of Mother's Own Milk on Fecal Calprotectin and of Gestational Age on IFABP Concentrations.Nutrients · 2025Article
- Elimination ofAntibiotics (Basel, Switzerland) · 2025Article
- The clinical characteristics and risk factors analysis within one week before the onset of necrotizing enterocolitis.Scientific reports · 2024Article
- Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024Article
- Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants.Nutrients · 2024Observational
- Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol.Pediatric research · 2024Article
- Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies.Nature communications · 2024Article
- Clinical Dilemma Involving Treatments for Very Low-Birth-Weight Infants and the Potential Risk of Necrotizing Enterocolitis: A Narrative Literature Review.Journal of clinical medicine · 2023Review
- New insights into the pathogenesis of necrotizing enterocolitis and the dawn of potential therapeutics.Seminars in pediatric surgery · 2023Review
- The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated withMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between the duration of antibiotic exposure and development of stage 2 or 3 necrotizing enterocolitis (NEC) in very preterm neonates. STUDY
designA retrospective case-control study was conducted from Canadian Neonatal Network data for preterm neonates born before 29 weeks' gestation and admitted 2010 through 2013. Efforts were made to match each NEC case to two controls for gestational age, birth weight (±100 g) and sex.
resultsA total of 224 cases and 447 controls were identified. The incidence of antenatal steroid administration, the number of days nil-per-os and the number of antibiotic days prior to onset of NEC were significantly different in neonates with NEC. A multiple regression analysis revealed that the duration of antibiotic use was higher among NEC cases compared to controls (P<0.01). Empiric antibiotic treatment of 5 or more days was associated with significantly increased odds of NEC as compared with antibiotic exposure of 0 to 4 days (adjusted odds ratio: 2.02; 95% CI 1.55, 3.13).
conclusionEmpiric antibiotic exposure for 5 or more days in preterm neonates born before 29 weeks' gestation was associated with an increased risk of NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.