ArticleNature microbiology2018
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 186 citations in OpenAlex.
- From predicted bacteriocins to ecological function.Current research in microbial sciences · 2026Review
- Exploring the antifungal activity of the wheat microbiome.Biochemical Society transactions · 2026Review
- Pairwise inoculation of plant growth-promoting rhizobacteria unveils predominant strain-specific effects in root growth and hormone-responsive promoter activity in Arabidopsis thaliana.Archives of microbiology · 2026Article
- A Bacterial Natural Product Reshapes Phyllosphere Microbiome Composition by Blocking Carotenoid Biosynthesis.bioRxiv : the preprint server for biology · 2026Article
- Surfactin-like lipopeptides contribute to interference competition of Bacillus velezensis against the marine Flavobacteriaceae in phycosphere.Environmental microbiome · 2026Article
- Article
- Phyllosphere microbes in foxtail millet primarily affect quality by modulating coloration and bitter compounds.Microbiome · 2025Article
- In Silico Prediction and In Vitro Validation of Bacterial Interactions in the Plant Rhizosphere Using a Synthetic Bacterial Community.Bio-protocol · 2025Article
- Toward a plant biotechnological application of phyllosphere bacteria.Plant biotechnology (Tokyo, Japan) · 2025Article
- Rapid and sustained differentiation of disease-suppressive phyllosphere microbiomes in tomato following experimental microbiome selection.Environmental microbiome · 2025Article
- Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation.Angewandte Chemie (International ed. in English) · 2025Article
- Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Differential Responses of Methylobacterium and Sphingomonas Species to Multispecies Interactions in the Phyllosphere.Environmental microbiology · 2025Article
- Strong pairwise interactions do not drive interactions in a plant leaf associated microbial community.ISME communications · 2025Article
- Harnessing the microbial interactions fromSynthetic and systems biotechnology · 2025Article
- Comprehensive genomic analysis of Brevibacillus brevis BF19 reveals its biocontrol potential against bitter gourd wilt.BMC microbiology · 2024Article
- Antibiotic-producing plant-associated bacteria, anti-virulence therapy and microbiome engineering: Integrated approaches in sustainable agriculture.Microbial biotechnology · 2024Article
- Fragmented micro-growth habitats present opportunities for alternative competitive outcomes.Nature communications · 2024Article
- Profiling of the Citrus Leaf Endophytic Mycobiota Reveals Abundant Pathogen-Related Fungal Groups.Journal of fungi (Basel, Switzerland) · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Plants are colonized by phylogenetically diverse microorganisms that affect plant growth and health. Representative genome-sequenced culture collections of bacterial isolates from model plants, including Arabidopsis thaliana, have recently been established. These resources provide opportunities for systematic interaction screens combined with genome mining to discover uncharacterized natural products. Here, we report on the biosynthetic potential of 224 strains isolated from the A. thaliana phyllosphere. Genome mining identified more than 1,000 predicted natural product biosynthetic gene clusters (BGCs), hundreds of which are unknown compared to the MIBiG database of characterized BGCs. For functional validation, we used a high-throughput screening approach to monitor over 50,000 binary strain combinations. We observed 725 inhibitory interactions, with 26 strains contributing to the majority of these. A combination of imaging mass spectrometry and bioactivity-guided fractionation of the most potent inhibitor, the BGC-rich Brevibacillus sp. Leaf182, revealed three distinct natural product scaffolds that contribute to the observed antibiotic activity. Moreover, a genome mining-based strategy led to the isolation of a trans-acyltransferase polyketide synthase-derived antibiotic, macrobrevin, which displays an unprecedented natural product structure. Our findings demonstrate that the phyllosphere is a valuable environment for the identification of antibiotics and natural products with unusual scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.