Evidence map›Paper›PMID 30038300›Full record

ArticleCell death & disease2018

METTL3 regulates WTAP protein homeostasis.

Melissa Sorci, Zaira Ianniello, Sonia Cruciani, Simone Larivera, Lavinia Ceci Ginistrelli, Ernestina Capuano, Marcella Marchioni, Francesco Fazi, Alessandro Fatica

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 137 citations in OpenAlex.

  1. mMolecular medicine reports · 2026
    Review
  2. Article
  3. The Emerging Role of METTL3 in Lung Diseases.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Regulatory mechanisms of mAmerican journal of translational research · 2025
    Review
  11. Article
  12. Role of mZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  13. A novel interaction between RNA mBiochemical and biophysical research communications · 2024
    Article
  14. Structures and mechanisms of the RNA mActa biochimica et biophysica Sinica · 2024
    Review
  15. Review
  16. NCellular and molecular life sciences : CMLS · 2024
    Review
  17. Review
  18. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  19. Article
  20. METTL3-dependent mCell death & disease · 2024
    Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Melissa SorciDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy.
Zaira IannielloDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy.
Sonia CrucianiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy.
Simone LariveraDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy.
Lavinia Ceci GinistrelliDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy.
Ernestina CapuanoDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, 00185, Rome, Italy.
Marcella MarchioniInstitute of Biology, Molecular Medicine and Nanobiotechnology, CNR, Sapienza University of Rome, Rome, Italy.
Francesco FaziDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, 00185, Rome, Italy.
Alessandro FaticaDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185, Rome, Italy. alessandro.fatica@uniroma1.it.
Sapienza University of Rome · ITIstituto Pasteur · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation. In addition, WTAP is also a regulator of the nuclear complex required for the deposition of N

Indexed as

Cell Cycle ProteinsCell Line, TumorHumansLeukemia, Myeloid, AcuteMethyltransferasesNuclear ProteinsProteostasisRibosomesRNA InterferenceRNA, Small InterferingRNA Splicing FactorsCell Cycle ProteinsMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanNuclear ProteinsRNA, Small InterferingRNA Splicing FactorsWTAP protein, human

Identifiers

PMID30038300
PMCPMC6056540
OpenAlexW2884940950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.