ArticleNature neuroscience2018
Fragility and volatility of structural hubs in the human connectome.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies.Brain imaging and behavior · 2022Pooled it
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Dose-dependent impairment of brain functional and microstructural connectivity during leukaemia chemotherapy.British journal of haematology · 2026Observational
- Brain idiosyncrasy during biological-motion perception is amplified in autistic individuals with intellectual impairment.Journal of neurodevelopmental disorders · 2026Article
- Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis.Human brain mapping · 2025Article
- Mapping and modeling age-related changes in intrinsic neural timescales.Communications biology · 2025Article
- Generation of surrogate brain maps preserving spatial autocorrelation through random rotation of geometric eigenmodes.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A simulated annealing algorithm for randomizing weighted networks.Nature computational science · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Metric structural human connectomes: Localization and multifractality of eigenmodes.Network neuroscience (Cambridge, Mass.) · 2025Article
- Flexibility of intrinsic neural timescales during distinct behavioral states.Communications biology · 2024Article
- Multimodal gradients of basal forebrain connectivity across the neocortex.Nature communications · 2024Article
- Interhemispheric functional connectivity: an fMRI study in callosotomized patients.Frontiers in human neuroscience · 2024Article
- Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Schizophrenia research · 2023Article
- Structural-functional coupling abnormalities in temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Trade-offs among cost, integration, and segregation in the human connectome.Network neuroscience (Cambridge, Mass.) · 2023Article
- Nonoptimal component placement of the human connectome supports variable brain dynamics.Network neuroscience (Cambridge, Mass.) · 2023Article
- Evolutionary shaping of human brain dynamics.eLife · 2022Article
- Preserved anatomical bypasses predict variance in language functions after stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.Nature communications · 2022Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computational advantages conferred by its complexity. We show that cost-neutral 'mutations' of the human connectome almost inevitably degrade its complexity and disconnect high-strength connections to prefrontal network hubs. Conversely, restoring the peripheral location and strong connectivity of empirically observed hubs confers a wiring cost that the brain appears to minimize. Progressive cost-neutral randomization yields daughter networks that differ substantially from one another and results in a topologically unstable phenomenon consistent with a phase transition in complex systems. The fragility of hubs to disconnection shows a significant association with the acceleration of gray matter loss in schizophrenia. Together with effects on wiring cost, we suggest that fragile prefrontal hub connections and topological volatility act as evolutionary influences on brain networks whose optimal set point may be perturbed in neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.