Evidence map›Paper›PMID 30038270›Full record

ArticleScientific reports2018

PDGFRA gene, maternal binge drinking and obstructive heart defects.

Xinyu Tang, Johann K Eberhart, Mario A Cleves, Jingyun Li, Ming Li, Stewart MacLeod, Wendy N Nembhard, Charlotte A Hobbs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. A Functional Synonymous Variant inJournal of Cancer · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xinyu TangBiostatistics Program, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA.
Johann K EberhartDepartment of Molecular and Cell and Developmental Biology, Institute for Cellular and Molecular Biology and Institute for Neuroscience, University of Texas, Austin, 78712, USA.
Mario A ClevesBiostatistics Program, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA.
Jingyun LiBiostatistics Program, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA.
Ming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University at Bloomington, Bloomington, 47405, USA.
Stewart MacLeodDivision of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA.
Wendy N NembhardDivision of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA.
Charlotte A HobbsDivision of Birth Defects Research, Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, 72202, USA. HobbsCharlotte@uams.edu.
University of Arkansas for Medical Sciences · USIndiana University Bloomington · USThe University of Texas at Austin · US

Funding

Genomic/Epigenomic Factors and Non-Syndromic Congenital Heart Defect Risk R01HD039054 · NICHD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI HOBBS, CHARLOTTE A · 2000 to 2016
$13.6M
Centers for Birth Defects Research and Prevention (CBDRPs)U01DD000491 · DD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI HOBBS, CHARLOTTE A · 2009 to 2013
$4.3M
Causes of Variability in Craniofacial DiseaseR01DE020884 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI EBERHART, JOHANN K · 2010 to 2019
$3.4M
Exploring the Genetics of FASD in Complementary Mouse and Fish ModelsU01AA021651 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EBERHART, JOHANN K, PARNELL, SCOTT · 2012 to 2021
$3.2M
Genetic Screens in Zebrafish to Identify Gene-Ethanol InteractionsR01AA023426 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI JOHANN K EBERHART · 2015 to 2026
$3.0M
Random Field Modelling of genetic and epigenetic association underlying congenital heart defects in the presence of disease heterogeneityK01HL140333 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI LI, MING · 2018 to 2021
$724k
NCBDD CDC HHS U01 DD000491NHLBI NIH HHS K01 HL140333NIAAA NIH HHS R01 AA023426NIAAA NIH HHS U01 AA021651NICHD NIH HHS R01 HD039054NIDCR NIH HHS R01 DE020884
6 · The paper itself

Abstract

Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. In this article, we investigated interactions between variants in PDGF genes and periconceptional alcohol exposure on the risk of OHDs by applying log-linear models to 806 OHD case and 995 control families enrolled in the National Birth Defects Prevention Study. The interactions between four variants in PDGFA and maternal binge drinking reached a nominal significance level. The maternal T allele of rs869978 was estimated to increase OHD risk among women who binge drink, while infant genotypes of rs2291591, rs2228230, rs1547904, and rs869978 may reduce the risk. Although none of these associations remain statistically significant after multiple testing adjustment and the estimated maternal effect may be influenced by unknown confounding factors, such as maternal smoking, these findings are consistent with previous animal studies supporting potential interactions between the PDGFRA gene and maternal alcohol exposure. Replication studies with larger sample sizes are needed to further elucidate this potential interplay and its influence on OHD risks.

Indexed as

Genetic Predisposition to DiseaseAdultBinge DrinkingFemaleHeart Defects, CongenitalHumansPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID30038270
PMCPMC6056529
OpenAlexW2883452314

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.