ArticleScientific reports2018
Cigarette Smoking Aggravates the Activity of Periodontal Disease by Disrupting Redox Homeostasis- An Observational Study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Evaluation of Salivary Biomarkers of Periodontal Disease Based on Smoking Status: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Salivary Osteocalcin as Potential Diagnostic Marker of Periodontal Bone Destruction among Smokers.Biomolecules · 2020Trial
- Low salivary thioredoxin-1 levels in periodontitis.World journal of clinical cases · 2026Article
- Gaps and Barriers Among Dental Undergraduates Towards Promoting and Assisting Tobacco Cessation: A Multicountry Cross-Sectional Study.International journal of dentistry · 2026Article
- Decoding different oxidative stress pathways in periodontitis: a comparative review of mechanisms of traditional tobacco smoke and electronic smoke aerosol.Archives of toxicology · 2025Review
- Periodontal Disease in Saudi Arabia: A Systematic Review of Prevalence and Associated Risk Factors.Diagnostics (Basel, Switzerland) · 2025Review
- YAG laser combined with mechanical debridement enhances pain relief and inflammation control in the management of periodontitis with peri-implantitis.American journal of translational research · 2025Article
- Analysis of protein interaction network in obesity linked with periodontitis.Bioinformation · 2024Article
- Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review.Cells · 2022Review
- Oral Health Literacy and Periodontal Disease in Primary Health Care Users.International dental journal · 2022Article
- Osteoporosis and periodontal diseases - An update on their association and mechanistic links.Periodontology 2000 · 2022Review
- Chronic metabolic and induced stress impacts mesenchymal stromal cell differentiation and modulation of dental originSaudi journal of biological sciences · 2022Article
- Salivary biomarkers as key to monitor personalized oral healthcare and precision dentistry: A scoping review.Frontiers in oral health · 2022Article
- Salivary Pro-Inflammatory Markers and Smoking Status Influences the Treatment Effectiveness of Periodontal Disease Patients with Hypertension.International journal of environmental research and public health · 2021Observational
- Review
- IL-8 as a Potential Therapeutic Target for Periodontitis and Its Inhibition by Caffeic Acid Phenethyl Ester In Vitro.International journal of molecular sciences · 2021Article
- Article
- Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials.Journal of inflammation research · 2021Review
- Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid.Nanomaterials (Basel, Switzerland) · 2020Article
- Periodontitis is associated with an increased risk for proximal colorectal neoplasms.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the associations between cigarette use and five salivary oxidative stress biomarkers, copper-zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (MnSOD), catalase, thioredoxin-1 (TRX1), and peroxiredoxin-2 (PRX2), to assess the effectiveness of non-surgical periodontal therapy. MATERIALS AND
methodsThis is an observational study,167 patients diagnosed with periodontitis were recruited. Both saliva samples and clinical measurements (plaque index (PI), bleeding on probing (BOP), and pocket depth (PD)) were taken at baseline and after completing non-surgical periodontal therapy. The Levels of salivary biomarkers were determined using a MILLIPLEX
conclusionsCigarette smoking interferes with redox homeostasis in the body, alters antioxidants levels, and influences the periodontal disease activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.