ArticleNature ecology & evolution2018
Gene exchange drives the ecological success of a multi-host bacterial pathogen.
Article in Nature ecology & evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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Who cites it
151 citing papers in PubMed.
- Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus.Communications biology · 2026Article
- Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-AssociatedMicroorganisms · 2026Article
- Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death.PLoS pathogens · 2026Article
- Plasmids of co-circulating Staphylococcus aureus serve as vehicles for antimicrobial resistance sharing across diseased host-species at short timescales.BMC microbiology · 2026Article
- Metagenomics comparison identifies shared pathogenic microbiome in humans, pigs and chickens.Applied microbiology and biotechnology · 2026Article
- Low Panton-Valentine leukocidin prevalence in circulating community MRSA: a genomic surveillance study in Qatar.BMC infectious diseases · 2026Article
- Diversity and evolution of leukotoxin operons inmSystems · 2026Article
- Genetic determinants of Staphylococcus aureus adhesion shape virulence trade-offs in bacteremia.Nature communications · 2026Article
- Molecular epidemiological analysis of Staphylococcus aureus from hospital and food in Huai'an, Jiangsu, China, based on whole genome sequencing.Scientific reports · 2026Article
- Pathoadaptive evolution and clonal dissemination of community- associated methicillin-resistant Staphylococcus aureus in Egypt.BMC infectious diseases · 2026Article
- A bacterial ecocline in Klebsiella pneumoniae may explain its backboned phylogeny.PLoS biology · 2026Article
- Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch.Science advances · 2026Article
- Comparative population genomic analysis of Brevibacterium casei isolated from a tuberculosis patient.Folia microbiologica · 2026Article
- Genomic characterization of non-CC398 methicillin-resistantFrontiers in public health · 2026Article
- Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status.Nature communications · 2025Article
- Genetic exchange networks bridge mobile DNA vehicles in the bacterial pathogen Listeria monocytogenes.Nature communications · 2025Article
- Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids.mSphere · 2025Article
- Comparative genomics of endemicmSphere · 2025Article
- Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- Development of a core genome multilocus sequence typing scheme and life identification number code classification system forMicrobial genomics · 2025Article
91 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors.
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Abstract
The capacity for some pathogens to jump into different host-species populations is a major threat to public health and food security. Staphylococcus aureus is a multi-host bacterial pathogen responsible for important human and livestock diseases. Here, using a population-genomic approach, we identify humans as a major hub for ancient and recent S. aureus host-switching events linked to the emergence of endemic livestock strains, and cows as the main animal reservoir for the emergence of human epidemic clones. Such host-species transitions are associated with horizontal acquisition of genetic elements from host-specific gene pools conferring traits required for survival in the new host-niche. Importantly, genes associated with antimicrobial resistance are unevenly distributed among human and animal hosts, reflecting distinct antibiotic usage practices in medicine and agriculture. In addition to gene acquisition, genetic diversification has occurred in pathways associated with nutrient acquisition, implying metabolic remodelling after a host switch in response to distinct nutrient availability. For example, S. aureus from dairy cattle exhibit enhanced utilization of lactose-a major source of carbohydrate in bovine milk. Overall, our findings highlight the influence of human activities on the multi-host ecology of a major bacterial pathogen, underpinned by horizontal gene transfer and core genome diversification.
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