ArticleNature medicine2018
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
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Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.
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164citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
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Who cites it
164 citing papers in PubMed, 253 citations in OpenAlex.
- Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- USP18 exacerbates myocardial I/R injury by inhibiting Parkin mitophagy through the deubiquitinase PTEN-L.Military Medical Research · 2026Article
- Inflammasome inhibition in myocardial infarction reduces early reperfusion injury and suppresses systemic plaque activation.Atherosclerosis · 2026Article
- Macrophage PIM1 Drives Atherosclerosis by Enhancing Foam Cell Formation Via CD36.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion Composition-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development.bioRxiv : the preprint server for biology · 2026Article
- Clonal haematopoiesis is associated with protection against angina pectoris in the UK population.Journal of advanced research · 2026Article
- Review
- VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair.Frontiers in immunology · 2026Review
- Gut microbiota as a causal mediator linking inflammatory cytokines and ageing phenotypes.Biogerontology · 2025Article
- Smooth muscle cells in atherosclerosis: essential but overlooked translational perspectives.European heart journal · 2025Review
- Endothelial MerTK impairment accelerates the development of atherosclerosis.Redox biology · 2025Article
- Targeted Anti-Inflammatory Therapy in Cardiovascular Events: Challenges and Opportunities.Journal of clinical hypertension (Greenwich, Conn.) · 2025Review
- Interleukin-1 Signaling on Vascular Smooth Muscle Cells Accelerates Atherosclerosis in a Murine Model of Kawasaki Disease.Journal of the American Heart Association · 2025Article
- Inflammasome Activation and Neutrophil Extracellular Traps in Atherosclerosis.Journal of atherosclerosis and thrombosis · 2025Review
- Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway.Current issues in molecular biology · 2025Article
- NLRP3 inflammasome in cardiovascular diseases: an update.Frontiers in immunology · 2025Review
- Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.Theranostics · 2025Article
- Inflammation and resolution in obesity.Nature reviews. Endocrinology · 2025 · on this mapReview
- Chronic inflammation and vascular cell plasticity in atherosclerosis.Nature cardiovascular research · 2024Review
104 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Delphine GomezRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-3880-6961
Richard A BaylisRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
Brittany G DurginRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
Alexandra A C NewmanRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-8938-2428
Gabriel F AlencarRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
Sidney MahanPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Cynthia St HilairePittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1871-6915
Werner MüllerFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-1297-9725
Ari WaismanInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-4304-8234
Sheila E FrancisDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-6552-0339
Emmanuel PinteauxFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Hermann GramNovartis Institutes for Biomedical Research, Basel, Switzerland.
Gary K OwensRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA. gko@virginia.edu.
University of Virginia · USUniversity of Pittsburgh · USUniversity of Manchester · GBJohannes Gutenberg University Mainz · DENovartis (Switzerland) · CHUniversity of Sheffield · GBWashington University in St. Louis · US
Funding
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MCancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4MT32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3MIL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1MOct4 and Klf4 regulate microvascular SMC-pericyte plasticity, angiogenesis, and metabolic dysfunctionR01HL135018 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$3.1MDefining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0MPDGFbeta Receptor Activation Promotes Atheroprotective Changes in SMC PhenotypeR01HL132904 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$2.6MRole of IL1b in Regulating SMC and Macrophage Differentiation in AtherosclerosisR01HL121008 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2014 to 2017
$2.2MRegulation of Vascular Calcification by Adenosine SignalingK22HL117917 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST. HILAIRE, CYNTHIA · 2015 to 2017
$731kIL1β Promotes Atheroprotective Changes in Late Stage Atherosclerotic LesionsF30HL136188 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLIS, RICHARD · 2017 to 2020
$144kBritish Heart Foundation PG/13/55/30365Medical Research Council G0801296NCI NIH HHS T32 CA009109NHLBI NIH HHS F30 HL136188NHLBI NIH HHS K22 HL117917NHLBI NIH HHS R01 HL121008NHLBI NIH HHS R01 HL132904NHLBI NIH HHS R01 HL135018NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141425NHLBI NIH HHS T32 HL007284NIDDK NIH HHS T32 DK007052
Abstract
Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we performed intervention studies in which smooth muscle cell (SMC) lineage-tracing Apoe
Indexed as
AnimalsAntibodies, NeutralizingApoptosisAtherosclerosisCell PolarityCell ProliferationDown-RegulationInflammationInterleukin-1betaMacrophagesMice, Inbred C57BLMonocytesMyocytes, Smooth MuscleNeutralization TestsPhenotypeSignal TransductionAntibodies, NeutralizingInterleukin-1beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.