Evidence map›Paper›PMID 30038214›Full record

ArticleMucosal immunology2018

Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection.

Hung-An Ting, Denise de Almeida Nagata, Andrew J Rasky, Carrie-Anne Malinczak, Ivan P Maillard, Matthew A Schaller, Nicholas W Lukacs

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Tregs tango with killer cells in acute infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Review
  10. The Dynamic Role of FOXP3Frontiers in immunology · 2022
    Review
  11. Notch signaling pathway in infectious diseases: role in the regulation of immune response.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Review
  12. Review
  13. Article
  14. Oncolytic HSV-Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  15. Review
  16. Review
  17. Notch signaling pathway regulates CD4Bioscience reports · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hung-An TingDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Denise de Almeida NagataDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Andrew J RaskyDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Carrie-Anne MalinczakDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Ivan P MaillardDepartment of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Matthew A SchallerDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Nicholas W LukacsDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA. nlukacs@umich.edu.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Notch Signaling in AlloimmunityR01AI091627 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEAR, WARREN S · 2011 to 2025
$6.0M
The Role of C-C Chemokines in Eosinophil Airway InflammationR01AI036302 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 2001 to 2018
$5.6M
Autophagy regulation of RSV-induced pulmonary diseaseR01HL114858 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOMBARD, DAVID BENNER, LUKACS, NICHOLAS W · 2012 to 2019
$3.2M
TLR and Notch Ligand in RSV-induced DiseaseR01AI073876 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 2008 to 2012
$1.9M
C-C CHEMOKINES AND EOSINOPHIL AIRWAY INFLAMMATIONR29AI036302 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 1996 to 2000
$107k
NHLBI NIH HHS R01 HL114858NIAID NIH HHS R01 AI036302NIAID NIH HHS R01 AI073876NIAID NIH HHS R01 AI091627NIAID NIH HHS R29 AI036302
6 · The paper itself

Abstract

Notch ligand Delta-like ligand 4 (DLL4) has been shown to regulate CD4 T-cell differentiation, including regulatory T cells (T

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCalcium-Binding ProteinsCell DifferentiationCells, CulturedDNA MethylationEpigenesis, GeneticFemaleForkhead Transcription FactorsHistone-Lysine N-MethyltransferaseHistonesImmune ToleranceIntracellular Signaling Peptides and ProteinsLymphocyte ActivationMembrane ProteinsMiceAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouseHistone-Lysine N-MethyltransferaseHistonesIntracellular Signaling Peptides and ProteinsMembrane ProteinsSmyd3 protein, mouse

Identifiers

PMID30038214
PMCPMC6160345
OpenAlexW2883875510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.