ArticleMolecular & cellular proteomics : MCP2018
hnRNPs Interacting with mRNA Localization Motifs Define Axonal RNA Regulons.
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Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- RBP-Driven RNA sorting and local translation establish the molecular identities of individual sensory axons.Nature communications · 2026Article
- RNArchitects: how hnRNPs shape neuronal landscapes.Brain : a journal of neurology · 2026Review
- The Role of Neuritin 1 in Synaptic Plasticity and Sensory Nerve Function: Integrator of Neurotrophic, Metabolic and Injury Signals.The European journal of neuroscience · 2026Review
- Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons of the cerebral cortex.Nature neuroscience · 2026Article
- From development to disease: the neuronal role of hnRNPs through the lens ofFrontiers in cell and developmental biology · 2026Review
- Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer.Journal of experimental & clinical cancer research : CR · 2025Article
- KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration.PLoS genetics · 2025Article
- Article
- Regulation of Subcellular Protein Synthesis for Restoring Neural Connectivity.International journal of molecular sciences · 2025Review
- The Role of Tau in Neuronal Function and Neurodegeneration.Neurology international · 2025Review
- Exploring potential mechanistic aspects of "Biaoben acupoint" acupuncture for lumbar disc herniation using 4D proteomics.Frontiers in neurology · 2025Article
- Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders.The Journal of cell biology · 2024Review
- hnRNPs: roles in neurodevelopment and implication for brain disorders.Frontiers in molecular neuroscience · 2024Review
- Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.Nucleic acids research · 2023Article
- PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.Science advances · 2023Article
- Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.Frontiers in cellular neuroscience · 2023Article
- KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.Communications biology · 2022Article
- Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs.Nucleic acids research · 2022Article
- A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Seung Joon LeeFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208.
Juan A Oses-Prieto§Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158.ORCID 0000-0003-4759-2341
Riki Kawaguchi¶Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-2489-4825
Pabitra K SahooFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208.ORCID 0000-0002-1076-9409
Amar N KarFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208.ORCID 0000-0003-2380-7504
Meir Rozenbaum‖Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.
David Oliver**Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208.
Shreya Chand§Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158.
Hao Ji**Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208.
Michael Shtutman**Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, 29208.ORCID 0000-0002-2458-3226
Sharmina Miller-RandolphFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208.
Ross J TaylorFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208.
Mike Fainzilber‖Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.ORCID 0000-0001-8173-8557
Giovanni Coppola¶Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0003-2105-1061
Alma L Burlingame§Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158.
Jeffery L TwissFrom the ‡Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208; twiss@mailbox.sc.edu.ORCID 0000-0001-7875-6682
University of South Carolina · USUniversity of California, San Francisco · USUniversity of California, Los Angeles · USWeizmann Institute of Science · IL
Funding
Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KIARIS, HIPPOKRATIS, RONINSON, IGOR B · 2014 to 2024
$25.2MBio-Organic Biomedical Mass Spectromy ResourceP41GM103481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURLINGAME, ALMA L · 2012 to 2015
$6.4MDestabilization of axonal mRNAs by KHSRP complexes during axon regenerationR01NS089633 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2015 to 2025
$4.1MTranslation during Nerve RegenerationR01NS041596 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2001 to 2018
$4.0MFunctional identification of new mechanisms of neurotoxicity induced by HIV and drugs of abuseR03DA043428 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SHTUTMAN, MICHAEL · 2017 to 2018
$293kNIDA NIH HHS R03 DA043428NIGMS NIH HHS P20 GM109091NIGMS NIH HHS P41 GM103481NINDS NIH HHS R01 NS041596NINDS NIH HHS R01 NS089633
Abstract
mRNA translation in axons enables neurons to introduce new proteins at sites distant from their cell body. mRNA-protein interactions drive this post-transcriptional regulation, yet knowledge of RNA binding proteins (RBP) in axons is limited. Here we used proteomics to identify RBPs interacting with the axonal localizing motifs of
Indexed as
5' Untranslated RegionsAnimalsAxonal TransportAxonsGAP-43 ProteinGPI-Linked ProteinsHeterogeneous-Nuclear RibonucleoproteinsHMGB1 ProteinMaleNeuropeptidesNucleotide MotifsProtein BindingProtein BiosynthesisRats, Sprague-DawleyRegulonRNA, Messenger5' Untranslated RegionsGAP-43 ProteinGPI-Linked ProteinsHeterogeneous-Nuclear RibonucleoproteinsHMGB1 ProteinNeuropeptidesNrn1 protein, ratRNA, MessengerAffinity proteomicsaxon growthBioinformaticshnRNPNeurobiologyRibonucleoproteinsRNA binding proteinSubcellular analysis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.