Evidence map›Paper›PMID 30038024›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mice harboring the human

Sandra Kleiner, Daniel Gomez, Bezawit Megra, Erqian Na, Ramandeep Bhavsar, Katie Cavino, Yurong Xin, Jose Rojas, Giselle Dominguez-Gutierrez, Brian Zambrowicz and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. A loss of function variant inmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Multiple genetic variants at thebioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Impact of anFrontiers in endocrinology · 2023
    Article
  16. Article
  17. Article
  18. Human genetics uncoversScience advances · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Sandra KleinerRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Daniel GomezRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Bezawit MegraRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Erqian NaRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Ramandeep BhavsarRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Katie CavinoRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Yurong XinRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Jose RojasRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Giselle Dominguez-GutierrezRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Brian ZambrowiczRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Gaelle CarratSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, United Kingdom.
Pauline ChabosseauSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, United Kingdom.
Ming HuSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, United Kingdom.
Andrew J MurphyRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
George D YancopoulosRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com jesper.gromada@regeneron.com.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, United Kingdom.
Jesper GromadaRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; george@regeneron.com jesper.gromada@regeneron.com.
Regeneron (United States) · USImperial College London · GB

Funding

Medical Research Council MR/J0003042/1Medical Research Council MR/K001981/1Medical Research Council MR/K023667/1Medical Research Council MR/L020149/1Medical Research Council MR/L02036X/1Medical Research Council MR/M012646/1Medical Research Council MR/N00275X/1Medical Research Council MR/N020472/1Medical Research Council MR/R010676/1Wellcome TrustWellcome Trust WT098424AIA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AllelesAnimalsBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalGene Knock-In TechniquesGlucoseHumansHyperglycemiaInsulinInsulin-Secreting CellsInsulin SecretionLoss of Function MutationMaleMiceMice, Inbred C57BLBlood GlucoseGlucoseInsulinPeptidesReceptor, InsulinS961 peptideSLC30A8 protein, humanSlc30a8 protein, mouseZinc Transporter 8genetic mutationinsulin secretionpancreatic beta cellSLC30A8zinc transporter

Identifiers

PMID30038024
PMCPMC6094147
OpenAlexW2883779697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.