Evidence map›Paper›PMID 30038018›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.

Oscar D Bello, Ouardane Jouannot, Arunima Chaudhuri, Ekaterina Stroeva, Jeff Coleman, Kirill E Volynski, James E Rothman, Shyam S Krishnakumar

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Integrative multi-omics identifiesPsychological medicine · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Phospholipids Differentially Regulate CaACS chemical biology · 2024
    Article
  8. c.1103T>C (p.Ile368Th) de novo Variant in Synaptotagmin 1 (International medical case reports journal · 2024
    Article
  9. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  11. Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Article
  15. Review
  16. Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Oscar D BelloDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Ouardane JouannotDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Arunima ChaudhuriDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Ekaterina StroevaDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Jeff ColemanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Kirill E VolynskiDepartment of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
James E RothmanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520; james.rothman@yale.edu shyam.krishnakumar@yale.edu.
Shyam S KrishnakumarDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520; james.rothman@yale.edu shyam.krishnakumar@yale.edu.ORCID 0000-0001-6148-3251
Yale University · USUniversity College London · GB

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Regulation of Membrane Fusion in ExocytosisR01DK027044 · NIDDK · YALE UNIVERSITY · PI KRISHNAKUMAR, SHYAM S · 1986 to 2021
$8.2M
MECHANISMS OF INTRACELLULAR MEMBRANE FUSIONR37DK027044 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, JAMES · 1992 to 2012
$5.3M
Medical Research Council G0600089Medical Research Council MC_UP_1502/1Medical Research Council MR/M013812/1NIDDK NIH HHS R01 DK027044NIDDK NIH HHS R37 DK027044NIGMS NIH HHS T32 GM007223Wellcome TrustWellcome Trust 104033
6 · The paper itself

Abstract

Regulated exocytosis, which underlies many intercellular signaling events, is a tightly controlled process often triggered by calcium ion(s) (Ca

Indexed as

ExocytosisAnimalsCalciumCations, DivalentCytoplasmic VesiclesFluorescent Antibody TechniqueGreen Fluorescent ProteinsMembrane FusionMicroscopy, ElectronMutationPC12 CellsProtein BindingProtein MultimerizationRatsRecombinant ProteinsSynaptotagmin ICalciumCations, DivalentGreen Fluorescent ProteinsPHluorinRecombinant ProteinsSynaptotagmin ISyt1 protein, ratVAMP2 protein, humanVesicle-Associated Membrane Protein 2calciumPC12 cellsregulated exocytosisSNARE proteinsynaptotagmin

Identifiers

PMID30038018
PMCPMC6094142
OpenAlexW2884695202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.