ArticleProceedings of the National Academy of Sciences of the United States of America2018
How adaptive immunity constrains the composition and fate of large bacterial populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A genomic catalog of the mouse gut virome reveals features associated with ageing.Nature communications · 2026Article
- Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences.PLoS biology · 2023Article
- Unveil the Secret of the Bacteria and Phage Arms Race.International journal of molecular sciences · 2023Review
- Article
- Phage Therapy: A Different Approach to Fight Bacterial Infections.Biologics : targets & therapy · 2022Review
- Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.Proceedings. Biological sciences · 2021Article
- Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback.iScience · 2021Article
- Searching for fat tails in CRISPR-Cas systems: Data analysis and mathematical modeling.PLoS computational biology · 2021Article
- The size of the immune repertoire of bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cost and benefits of clustered regularly interspaced short palindromic repeats spacer acquisition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Features of the CRISPR-Cas system, in which bacteria integrate small segments of phage genome (spacers) into their DNA to neutralize future attacks, suggest that its effect is not limited to individual bacteria but may control the fate and structure of whole populations. Emphasizing the population-level impact of the CRISPR-Cas system, recent experiments show that some bacteria regulate CRISPR-associated genes via the quorum sensing (QS) pathway. Here we present a model that shows that from the highly stochastic dynamics of individual spacers under QS control emerges a rank-abundance distribution of spacers that is time invariant, a surprising prediction that we test with dynamic spacer-tracking data from literature. This distribution depends on the state of the competing phage-bacteria population, which due to QS-based regulation may coexist in multiple stable states that vary significantly in their phage-to-bacterium ratio, a widely used ecological measure to characterize microbial systems.
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