Evidence map›Paper›PMID 30038005›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.

Maiara S Severo, Jonathan J M Landry, Randall L Lindquist, Christian Goosmann, Volker Brinkmann, Paul Collier, Anja E Hauser, Vladimir Benes, Johan Henriksson, Sarah A Teichmann and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  6. International journal of molecular sciences · 2025
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  12. Article
  13. A single-cell atlas of thebioRxiv : the preprint server for biology · 2024
    Article
  14. Exploring new dimensions of immune cell biology inbioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Article
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  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maiara S SeveroVector Biology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
Jonathan J M LandryGenomics Core Facility, European Molecular Biology Laboratories, 69117 Heidelberg, Germany.
Randall L LindquistImmunodynamics, Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany.
Christian GoosmannMicroscopy Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
Volker BrinkmannMicroscopy Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
Paul CollierGenomics Core Facility, European Molecular Biology Laboratories, 69117 Heidelberg, Germany.
Anja E HauserImmunodynamics, Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany.
Vladimir BenesGenomics Core Facility, European Molecular Biology Laboratories, 69117 Heidelberg, Germany.
Johan HenrikssonCellular Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Sarah A TeichmannCellular Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Elena A LevashinaVector Biology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany; levashina@mpiib-berlin.mpg.de.ORCID 0000-0003-4605-906X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mosquito blood cells are immune cells that help control infection by vector-borne pathogens. Despite their importance, little is known about mosquito blood cell biology beyond morphological and functional criteria used for their classification. Here, we combined the power of single-cell RNA sequencing, high-content imaging flow cytometry, and single-molecule RNA hybridization to analyze a subset of blood cells of the malaria mosquito

Indexed as

AnimalsAnimals, Genetically ModifiedAnophelesBlood CellsCell CommunicationCell PlasticityDatasets as TopicFemaleGenomicsMalariaMosquito VectorsRNASequence Analysis, RNASingle-Cell AnalysisTranscriptomeRNAblood cellsentomologyinsect immunitymalariasingle-cell sequencing

Identifiers

PMID30038005
PMCPMC6094101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.