Evidence map›Paper›PMID 30038002›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Zinc depletion induces ribosome hibernation in mycobacteria.

Yunlong Li, Manjuli R Sharma, Ravi K Koripella, Yong Yang, Prem S Kaushal, Qishan Lin, Joseph T Wade, Todd A Gray, Keith M Derbyshire, Rajendra K Agrawal and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Ribosome hibernation in zinc-starvedMicrobiology spectrum · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. iScience · 2026
    Article
  7. Article
  8. Journal of bacteriology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Exploring metalloproteome remodeling in calprotectin-stressedbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yunlong LiDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Manjuli R SharmaDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201.
Ravi K KoripellaDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201.
Yong YangDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Prem S KaushalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201.
Qishan LinProteomics/Mass Spectrometry Facility, Center for Functional Genomics, University at Albany, Rensselaer, NY 12144.
Joseph T WadeDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Todd A GrayDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.ORCID 0000-0003-0931-5503
Keith M DerbyshireDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.ORCID 0000-0003-3404-8312
Rajendra K AgrawalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201; Rajendra.Agrawal@health.ny.gov Anil.Ojha@health.ny.gov.
Anil K OjhaDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208; Rajendra.Agrawal@health.ny.gov Anil.Ojha@health.ny.gov.ORCID 0000-0001-5940-2643
New York State Department of Health · USUniversity at Albany, State University of New York · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Structural Aspects of Protein Synthesis in the Mammalian MitochondriaR01GM061576 · NIGMS · WADSWORTH CENTER · PI AGRAWAL, RAJENDRA K · 2001 to 2018
$6.4M
Alternative Ribosomes & Antibiotic Tolerance in MycobacteriaR01AI132422 · NIAID · WADSWORTH CENTER · PI RAJENDRA K AGRAWAL, Anil Kumar Ojha · 2017 to 2026
$3.8M
A Community Mycobacterial Systems ResourceR01AI097191 · NIAID · WADSWORTH CENTER · PI DERBYSHIRE, KEITH M, FORTUNE, SARAH · 2012 to 2016
$3.2M
Enzyme-based lysis of mycobacteriaR21AI107595 · NIAID · WADSWORTH CENTER · PI OJHA, ANIL KUMAR · 2014 to 2015
$390k
NIAID NIH HHS R01 AI097191NIAID NIH HHS R01 AI132422NIAID NIH HHS R21 AI107595NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM061576
6 · The paper itself

Abstract

Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-binding CXXC motif (C+) with their zinc-free (C-) paralogues. Consequences of this process beyond zinc homeostasis are unknown. Here, we show that the C- ribosome in

Indexed as

AminoglycosidesAnimalsAntibiotics, AntitubercularBacterial ProteinsCryoelectron MicroscopyDisease Models, AnimalDrug Resistance, BacterialFemaleHumansMiceMice, Inbred C57BLMicrobial Sensitivity TestsModels, MolecularMycobacterium smegmatisMycobacterium tuberculosisProtein BiosynthesisAminoglycosidesAntibiotics, AntitubercularBacterial ProteinsRibosomal ProteinsZincantibioticsC− ribosomecryo-EMMPYMRF

Identifiers

PMID30038002
PMCPMC6094098
OpenAlexW2883603281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.