Evidence map›Paper›PMID 30037897›Full record

ArticleEMBO reports2018

The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization.

Pedro Prudêncio, Leonardo G Guilgur, João Sobral, Jörg D Becker, Rui Gonçalo Martinho, Paulo Navarro-Costa

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Genetic and Epigenetic Regulation ofJournal of developmental biology · 2023
    Review
  5. Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pedro PrudêncioCenter for Biomedical Research and Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal.
Leonardo G GuilgurInstituto Gulbenkian de Ciência, Oeiras, Portugal.
João SobralInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Jörg D BeckerInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Rui Gonçalo MartinhoCenter for Biomedical Research and Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal rgmartinho@ualg.pt navarro-costa@medicina.ulisboa.pt.ORCID 0000-0002-1641-3403
Paulo Navarro-CostaCenter for Biomedical Research and Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal rgmartinho@ualg.pt navarro-costa@medicina.ulisboa.pt.ORCID 0000-0002-8543-4179
Instituto Gulbenkian de Ciência · PTUniversity of Lisbon · PTAlgarve Biomedical Center · PT

Funding

Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
NIGMS NIH HHS R01 GM084947
6 · The paper itself

Abstract

The transition from fertilized oocyte to totipotent embryo relies on maternal factors that are synthetized and accumulated during oocyte development. Yet, it is unclear how oocytes regulate the expression of maternal genes within the transcriptional program of oogenesis. Here, we report that the

Indexed as

GenomeAnimalsDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentEmbryo, NonmammalianFemaleFertilizationGerm CellsGlycoproteinsHistone-Lysine N-MethyltransferaseIntracellular Signaling Peptides and ProteinsMaleMeiosisOocytesOogenesisDrosophila ProteinsGlycoproteinsHistone-Lysine N-MethyltransferaseIdgf4 protein, DrosophilaIntracellular Signaling Peptides and ProteinsTRR protein, DrosophilachromatinDrosophilafertilizationTrithoraxzygote

Identifiers

PMID30037897
PMCPMC6073209
OpenAlexW2951261902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.