Evidence map›Paper›PMID 30037854›Full record

ReviewMolecular cancer research : MCR2018

SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.

Takeshi Fukumoto, Elizabeth Magno, Rugang Zhang

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of SMARCA4 in lung cancer.Scientific reports · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. PRMT3 and CARM1: Emerging Epigenetic Targets in Cancer.Journal of cellular and molecular medicine · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Advances in the role of SWI/SNF complexes in tumours.Journal of cellular and molecular medicine · 2023
    Review
  12. Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  13. The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries.International journal of molecular sciences · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Takeshi FukumotoGene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Elizabeth MagnoGene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania.
Rugang ZhangGene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania. rzhang@wistar.org.
The Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancerR01CA202919 · NCI · WISTAR INSTITUTE · PI Xi Chen, Rugang Zhang · 2016 to 2026
$4.1M
Role of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0M
Targeting EZH2 in CARM1-expressing epithelial ovarian cancerR01CA163377 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$3.7M
NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA160331NCI NIH HHS R01 CA163377NCI NIH HHS R01 CA202919
6 · The paper itself

Abstract

Ovarian cancer remains the most lethal gynecologic malignancy in the developed world. Despite the unprecedented progress in understanding the genetics of ovarian cancer, cures remain elusive due to a lack of insight into the mechanisms that can be targeted to develop new therapies. SWI/SNF chromatin remodeling complexes are genetically altered in approximately 20% of all human cancers. SWI/SNF alterations vary in different histologic subtypes of ovarian cancer, with

Indexed as

Antineoplastic AgentsCARD Signaling Adaptor ProteinsClinical Trials as TopicDNA-Binding ProteinsDNA HelicasesFemaleGene AmplificationGene Expression Regulation, NeoplasticGuanylate CyclaseHumansMutationNuclear ProteinsOvarian NeoplasmsPrecision MedicineSignal TransductionTranscription FactorsAntineoplastic AgentsARID1A protein, humanCARD11 protein, humanCARD Signaling Adaptor ProteinsDNA-Binding ProteinsDNA HelicasesGuanylate CyclaseNuclear ProteinsSMARCA4 protein, humanTranscription Factors

Identifiers

PMID30037854
PMCPMC6279546
OpenAlexW2884631604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.