Evidence map›Paper›PMID 30037851›Full record

ReviewThe Journal of general physiology2018

Structure, function, and allosteric modulation of NMDA receptors.

Kasper B Hansen, Feng Yi, Riley E Perszyk, Hiro Furukawa, Lonnie P Wollmuth, Alasdair J Gibb, Stephen F Traynelis

Registry-linked trialAbstract readReview
In one paragraph

Review in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06021717 (PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery), which is not on this map. Cited by 297 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06021717 phase4completednot on this map

PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery

TypeinterventionalSponsorUniversiti Kebangsaan Malaysia Medical CentreRan2018 to 2019Enrolled60ConditionsKetamine, MorphineArmsKetamine-Morphine, Morphine
3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Ketamine treatment for refractory anxiety: A systematic review.British journal of clinical pharmacology · 2022
    Pooled it
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
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  16. Article
  17. Review
  18. A Study of 3-Substituted 7-Methoxy-2,3,4,5-tetrahydro-1Molecules (Basel, Switzerland) · 2026
    Article
  19. Review
  20. Article

237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kasper B HansenDepartment of Biomedical and Pharmaceutical Sciences and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT.ORCID 0000-0002-3303-4819
Feng YiDepartment of Biomedical and Pharmaceutical Sciences and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT.ORCID 0000-0002-0049-742X
Riley E PerszykDepartment of Pharmacology, Emory University School of Medicine, Atlanta, GA.
Hiro FurukawaCold Spring Harbor Laboratory, Cold Spring Harbor, NY.
Lonnie P WollmuthDepartments of Neurobiology & Behavior and Biochemistry & Cell Biology, Stony Brook University, Stony Brook, NY.ORCID 0000-0002-8179-1259
Alasdair J GibbDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Stephen F TraynelisDepartment of Pharmacology, Emory University School of Medicine, Atlanta, GA strayne@emory.edu.ORCID 0000-0002-3750-9615

Funding

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP20GM103546 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2012 to 2021
$19.2M
Structures and reagents of NMDA receptorsR01MH085926 · NIMH · COLD SPRING HARBOR LABORATORY · PI Hiroyasu Furukawa · 2010 to 2026
$8.9M
Graduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1M
Minority Supplement for Noele CertainR01NS088479 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI WOLLMUTH, LONNIE P · 2015 to 2023
$3.9M
Control of Glutamate Receptor FunctionR01NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 1998 to 2018
$3.7M
Mechanism of Action of Novel Subunit-Selective NMDA Receptor ModulatorsR01NS065371 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2009 to 2018
$3.4M
Structural and functional investigation of negative allosteric NMDA receptor modulationR01NS097536 · NINDS · UNIVERSITY OF MONTANA · PI Kasper Boe Hansen · 2016 to 2026
$3.4M
Control of glutamate receptor functionR37NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2007 to 2013
$2.4M
STRUCTURE AND FUNCTION OF HETERO-MULTIMERIC GLUTAMATE RECEPTORSR01GM105730 · NIGMS · COLD SPRING HARBOR LABORATORY · PI FURUKAWA, HIROYASU · 2014 to 2017
$2.0M
NIGMS NIH HHS P20 GM103546NIGMS NIH HHS R01 GM105730NIGMS NIH HHS T32 GM008602NIMH NIH HHS R01 MH085926NINDS NIH HHS R01 NS036654NINDS NIH HHS R01 NS065371NINDS NIH HHS R01 NS088479NINDS NIH HHS R01 NS097536NINDS NIH HHS R37 NS036654
6 · The paper itself

Abstract

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca

Indexed as

AnimalsHumansIonsProtein Structure, QuaternaryReceptors, N-Methyl-D-AspartateIonsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID30037851
PMCPMC6080888

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.