ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Beyond Trial-Based Paradigms: Continuous Behavior, Ongoing Neural Activity, and Natural Stimuli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Color discrimination in action: High-throughput measurement in immersive VR.Journal of vision · 2026Article
- Preferred visual experiences provide intuitive descriptions of the functional properties of the cortical navigation network.bioRxiv : the preprint server for biology · 2026Article
- Neural mechanisms of time-forward predictions for naturalistic auditory tone sequences.Nature communications · 2026Article
- Task-induced topological and geometrical changes in whole-brain dynamics predict cognitive individual differences.bioRxiv : the preprint server for biology · 2026Article
- A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- The Impact of Simulated Anisometropia and Bilateral Defocus on Reflex Vergence Responses of Children and Adults.Investigative ophthalmology & visual science · 2026Article
- A diffusion model analysis of task set inertia and task set reconfiguration in ADHD.Journal of the International Neuropsychological Society : JINS · 2026Article
- Sensory Attenuation of Auditory P2 Responses is Modulated by the Sense of Action Timing Control.Psychophysiology · 2025Article
- Speed modulations in grid cell information geometry.Nature communications · 2025Article
- Functional Importance Backbones of the Brain at Rest, Wakefulness, and Sleep.Brain sciences · 2025Article
- Infra-slow scale-free dynamics modulate the connection of neural and behavioral variability during attention.Communications biology · 2025Article
- Measuring spatial and temporal properties of visual crowding using continuous psychophysics.Journal of vision · 2025Article
- Foraging animals use dynamic Bayesian updating to model meta-uncertainty in environment representations.PLoS computational biology · 2025Article
- A comparative analysis of perceptual noise in lateral and depth motion: Evidence from eye tracking.Journal of vision · 2025Article
- Affective integration in experience, judgment, and decision-making.Communications psychology · 2024Review
- Flexibility of intrinsic neural timescales during distinct behavioral states.Communications biology · 2024Article
- Biomarker discovery using machine learning in the psychosis spectrum.Biomarkers in neuropsychiatry · 2024Article
- Linking brain-heart interactions to emotional arousal in immersive virtual reality.Psychophysiology · 2024Article
- Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors.eLife · 2024Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
The vast majority of experiments examining perception and behavior are conducted using experimental paradigms that adhere to a rigid trial structure: each trial consists of a brief and discrete series of events and is regarded as independent from all other trials. The assumptions underlying this structure ignore the reality that natural behavior is rarely discrete, brain activity follows multiple time courses that do not necessarily conform to the trial structure, and the natural environment has statistical structure and dynamics that exhibit long-range temporal correlation. Modern advances in statistical modeling and analysis offer tools that make it feasible for experiments to move beyond rigid independent and identically distributed trial structures. Here we review literature that serves as evidence for the feasibility and advantages of moving beyond trial-based paradigms to understand the neural basis of perception and cognition. Furthermore, we propose a synthesis of these efforts, integrating the characterization of natural stimulus properties with measurements of continuous neural activity and behavioral outputs within the framework of sensory-cognitive-motor loops. Such a framework provides a basis for the study of natural statistics, naturalistic tasks, and/or slow fluctuations in brain activity, which should provide starting points for important generalizations of analytical tools in neuroscience and subsequent progress in understanding the neural basis of perception and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.